OPA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0000266Biological processmitochondrial fission
GO_1902236Biological processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0007007Biological processinner mitochondrial membrane organization
GO_0046039Biological processGTP metabolic process
GO_0032740Biological processpositive regulation of interleukin-17 production
GO_0090201Biological processnegative regulation of release of cytochrome c from mitochondria
GO_0061025Biological processmembrane fusion
GO_0008053Biological processmitochondrial fusion
GO_0051259Biological processprotein complex oligomerization
GO_0007005Biological processmitochondrion organization
GO_0043066Biological processnegative regulation of apoptotic process
GO_0042407Biological processcristae formation
GO_1990627Biological processmitochondrial inner membrane fusion
GO_0001843Biological processneural tube closure
GO_0097749Biological processmembrane tubulation
GO_0006915Biological processapoptotic process
GO_0090398Biological processcellular senescence
GO_2000330Biological processpositive regulation of T-helper 17 cell lineage commitment
GO_0019896Biological processaxonal transport of mitochondrion
GO_0000002Biological processmitochondrial genome maintenance
GO_0005874Cellular componentmicrotubule
GO_0030061Cellular componentmitochondrial crista
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005654Cellular componentnucleoplasm
GO_0005743Cellular componentmitochondrial inner membrane
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_1904115Cellular componentaxon cytoplasm
GO_0140523Molecular functionGTPase-dependent fusogenic activity
GO_0180020Molecular functionmembrane bending activity
GO_0000287Molecular functionmagnesium ion binding
GO_0005525Molecular functionGTP binding
GO_0008017Molecular functionmicrotubule binding
GO_0070300Molecular functionphosphatidic acid binding
GO_1901612Molecular functioncardiolipin binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameOPA1
Protein nameOPA1 mitochondrial dynamin like GTPase
Dynamin-like 120 kDa protein, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1) [Cleaved into: Dynamin-like 120 kDa protein, form S1]
Dynamin-like 120 kDa protein, mitochondrial (EC 3.6.5.5)
SynonymsKIAA0567
hCG_17270
DescriptionFUNCTION: Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission . Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion . Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation . The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes . Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance . .; FUNCTION: [Dynamin-like 120 kDa protein, form S1]: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion. .; FUNCTION: [Isoform 4]: Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane. .; FUNCTION: [Isoform 5]: Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane. .

AccessionsENST00000646793.1 [O60313-13]
ENST00000646544.1
A0A2R8YDM2
ENST00000645553.1
ENST00000361150.6 [O60313-9]
E5KLJ9
A0A2R8Y4Q3
ENST00000642289.1
ENST00000643737.1
A0A2R8Y514
ENST00000644959.1
ENST00000445863.1
C9JY58
ENST00000392436.7
A0A2R8YD53
A0A2R8YE78
ENST00000643329.1
A0A2R8YFD1
E5KLK0
A0A2R8Y3X5
ENST00000644841.1
A0A2R8Y4G4
A0A2R8Y5G3
ENST00000361510.8 [O60313-10]
A0A2R8Y5E2
ENST00000392437.6 [O60313-11]
ENST00000361908.8 [O60313-2]
ENST00000642445.1
ENST00000646085.1
ENST00000361715.6
ENST00000646699.1
ENST00000642593.1
ENST00000646277.1
H7C3G2
ENST00000429164.1
ENST00000419435.5
A0A2R8YGE5
C9JMB8
ENST00000644595.1
H7C141
ENST00000434811.2
O60313
H7C321
A0A2R8YE54
ENST00000644629.1
ENST00000361828.7 [O60313-1]