Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 14 studies | 29% ± 12% | |
| glutamatergic neuron | 11 studies | 43% ± 24% | |
| oligodendrocyte | 11 studies | 30% ± 11% | |
| oligodendrocyte precursor cell | 10 studies | 30% ± 14% | |
| astrocyte | 10 studies | 34% ± 15% | |
| GABAergic neuron | 9 studies | 41% ± 20% | |
| microglial cell | 9 studies | 26% ± 9% | |
| epithelial cell | 7 studies | 31% ± 12% | |
| neuron | 6 studies | 28% ± 10% | |
| interneuron | 6 studies | 43% ± 23% | |
| fibroblast | 6 studies | 23% ± 6% | |
| adipocyte | 5 studies | 25% ± 2% | |
| endothelial cell of lymphatic vessel | 5 studies | 25% ± 5% | |
| macrophage | 5 studies | 33% ± 8% | |
| granule cell | 4 studies | 24% ± 4% | |
| myeloid cell | 4 studies | 20% ± 3% | |
| cardiac muscle cell | 4 studies | 20% ± 2% | |
| dendritic cell | 4 studies | 24% ± 8% | |
| lymphocyte | 4 studies | 22% ± 6% | |
| monocyte | 4 studies | 23% ± 2% | |
| pericyte | 4 studies | 23% ± 7% | |
| smooth muscle cell | 4 studies | 18% ± 1% | |
| GABAergic interneuron | 3 studies | 29% ± 1% | |
| retinal ganglion cell | 3 studies | 42% ± 3% | |
| ciliated cell | 3 studies | 22% ± 2% | |
| hepatocyte | 3 studies | 35% ± 23% | |
| alveolar macrophage | 3 studies | 25% ± 8% | |
| natural killer cell | 3 studies | 17% ± 1% | |
| basal cell | 3 studies | 31% ± 20% | |
| transit amplifying cell | 3 studies | 35% ± 22% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3829.91 | 1445 / 1445 | 100% | 50.97 | 183 / 183 |
| ovary | 100% | 2971.10 | 180 / 180 | 100% | 22.33 | 430 / 430 |
| uterus | 100% | 3408.06 | 170 / 170 | 100% | 34.60 | 459 / 459 |
| breast | 100% | 3558.79 | 459 / 459 | 100% | 37.98 | 1117 / 1118 |
| brain | 100% | 4633.46 | 2639 / 2642 | 100% | 33.22 | 705 / 705 |
| bladder | 100% | 3682.29 | 21 / 21 | 100% | 28.91 | 503 / 504 |
| prostate | 100% | 2964.96 | 245 / 245 | 100% | 23.11 | 501 / 502 |
| lung | 99% | 2707.41 | 574 / 578 | 100% | 36.41 | 1155 / 1155 |
| intestine | 100% | 4125.90 | 966 / 966 | 99% | 30.00 | 523 / 527 |
| pancreas | 100% | 1856.24 | 327 / 328 | 99% | 22.65 | 177 / 178 |
| adrenal gland | 100% | 4591.67 | 258 / 258 | 99% | 22.16 | 228 / 230 |
| thymus | 100% | 3305.84 | 653 / 653 | 99% | 21.75 | 599 / 605 |
| kidney | 100% | 2724.10 | 89 / 89 | 99% | 24.21 | 892 / 901 |
| stomach | 100% | 3067.83 | 359 / 359 | 99% | 31.14 | 283 / 286 |
| liver | 100% | 2329.77 | 226 / 226 | 98% | 16.35 | 398 / 406 |
| skin | 100% | 4235.04 | 1809 / 1809 | 97% | 30.65 | 459 / 472 |
| adipose | 100% | 3681.96 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3677.57 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 5454.42 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2810.39 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 42.36 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 8.27 | 1 / 1 |
| heart | 97% | 4472.71 | 832 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 22.31 | 28 / 29 |
| eye | 0% | 0 | 0 / 0 | 81% | 10.93 | 65 / 80 |
| peripheral blood | 63% | 2143.13 | 581 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007601 | Biological process | visual perception |
| GO_0000266 | Biological process | mitochondrial fission |
| GO_1902236 | Biological process | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| GO_0007007 | Biological process | inner mitochondrial membrane organization |
| GO_0046039 | Biological process | GTP metabolic process |
| GO_0032740 | Biological process | positive regulation of interleukin-17 production |
| GO_0090201 | Biological process | negative regulation of release of cytochrome c from mitochondria |
| GO_0061025 | Biological process | membrane fusion |
| GO_0008053 | Biological process | mitochondrial fusion |
| GO_0051259 | Biological process | protein complex oligomerization |
| GO_0007005 | Biological process | mitochondrion organization |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0042407 | Biological process | cristae formation |
| GO_1990627 | Biological process | mitochondrial inner membrane fusion |
| GO_0001843 | Biological process | neural tube closure |
| GO_0097749 | Biological process | membrane tubulation |
| GO_0006915 | Biological process | apoptotic process |
| GO_0090398 | Biological process | cellular senescence |
| GO_2000330 | Biological process | positive regulation of T-helper 17 cell lineage commitment |
| GO_0019896 | Biological process | axonal transport of mitochondrion |
| GO_0000002 | Biological process | mitochondrial genome maintenance |
| GO_0005874 | Cellular component | microtubule |
| GO_0030061 | Cellular component | mitochondrial crista |
| GO_0016020 | Cellular component | membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0031966 | Cellular component | mitochondrial membrane |
| GO_0005758 | Cellular component | mitochondrial intermembrane space |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005743 | Cellular component | mitochondrial inner membrane |
| GO_0030425 | Cellular component | dendrite |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005741 | Cellular component | mitochondrial outer membrane |
| GO_1904115 | Cellular component | axon cytoplasm |
| GO_0140523 | Molecular function | GTPase-dependent fusogenic activity |
| GO_0180020 | Molecular function | membrane bending activity |
| GO_0000287 | Molecular function | magnesium ion binding |
| GO_0005525 | Molecular function | GTP binding |
| GO_0008017 | Molecular function | microtubule binding |
| GO_0070300 | Molecular function | phosphatidic acid binding |
| GO_1901612 | Molecular function | cardiolipin binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003924 | Molecular function | GTPase activity |
| Gene name | OPA1 |
| Protein name | OPA1 mitochondrial dynamin like GTPase Dynamin-like 120 kDa protein, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1) [Cleaved into: Dynamin-like 120 kDa protein, form S1] Dynamin-like 120 kDa protein, mitochondrial (EC 3.6.5.5) |
| Synonyms | KIAA0567 hCG_17270 |
| Description | FUNCTION: Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission . Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion . Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation . The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes . Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance . .; FUNCTION: [Dynamin-like 120 kDa protein, form S1]: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion. .; FUNCTION: [Isoform 4]: Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane. .; FUNCTION: [Isoform 5]: Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane. . |
| Accessions | ENST00000646793.1 [O60313-13] ENST00000646544.1 A0A2R8YDM2 ENST00000645553.1 ENST00000361150.6 [O60313-9] E5KLJ9 A0A2R8Y4Q3 ENST00000642289.1 ENST00000643737.1 A0A2R8Y514 ENST00000644959.1 ENST00000445863.1 C9JY58 ENST00000392436.7 A0A2R8YD53 A0A2R8YE78 ENST00000643329.1 A0A2R8YFD1 E5KLK0 A0A2R8Y3X5 ENST00000644841.1 A0A2R8Y4G4 A0A2R8Y5G3 ENST00000361510.8 [O60313-10] A0A2R8Y5E2 ENST00000392437.6 [O60313-11] ENST00000361908.8 [O60313-2] ENST00000642445.1 ENST00000646085.1 ENST00000361715.6 ENST00000646699.1 ENST00000642593.1 ENST00000646277.1 H7C3G2 ENST00000429164.1 ENST00000419435.5 A0A2R8YGE5 C9JMB8 ENST00000644595.1 H7C141 ENST00000434811.2 O60313 H7C321 A0A2R8YE54 ENST00000644629.1 ENST00000361828.7 [O60313-1] |