RNF34 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_2001271Biological processnegative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO_2000374Biological processregulation of oxygen metabolic process
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0070417Biological processcellular response to cold
GO_0070936Biological processprotein K48-linked ubiquitination
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0006915Biological processapoptotic process
GO_1902042Biological processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0035872Biological processnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO_1901797Biological processnegative regulation of signal transduction by p53 class mediator
GO_0005886Cellular componentplasma membrane
GO_0012505Cellular componentendomembrane system
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0002039Molecular functionp53 binding
GO_0046872Molecular functionmetal ion binding
GO_1901981Molecular functionphosphatidylinositol phosphate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRNF34
Protein nameRing finger protein 34
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34)
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis . May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation . Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN . Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells . Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation . .

AccessionsENST00000557402.1
G3V504
G3V4D1
ENST00000555076.1
ENST00000392465.7 [Q969K3-2]
ENST00000554868.1
Q969K3
ENST00000392464.3
H7BYJ1
A0A087WTM5
ENST00000554606.5
ENST00000613529.4
G3V5F1
ENST00000361234.10 [Q969K3-1]
G3V566