BIRC7 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of BIRC7 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BIRC7 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0070247Biological processregulation of natural killer cell apoptotic process
GO_0046330Biological processpositive regulation of JNK cascade
GO_0042981Biological processregulation of apoptotic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0002088Biological processlens development in camera-type eye
GO_0006915Biological processapoptotic process
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0042127Biological processregulation of cell population proliferation
GO_0051726Biological processregulation of cell cycle
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004869Molecular functioncysteine-type endopeptidase inhibitor activity
GO_0019899Molecular functionenzyme binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0043027Molecular functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO_0046872Molecular functionmetal ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBIRC7
Protein nameBaculoviral IAP repeat-containing 7
Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)]
Baculoviral IAP repeat containing 7
SynonymsLIVIN
UNQ5800/PRO19607/PRO21344
MLIAP
RNF50
KIAP
DescriptionFUNCTION: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control . Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity . As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival . May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions . Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine . Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2 . This activation depends on TAB1 and MAP3K7/TAK1 . In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9 . .; FUNCTION: [Isoform 1]: Blocks staurosporine-induced apoptosis . Promotes natural killer (NK) cell-mediated killing . .; FUNCTION: [Isoform 2]: Blocks etoposide-induced apoptosis . Protects against natural killer (NK) cell-mediated killing . .

AccessionsA8MTF4
ENST00000395306.1
Q6R308
Q96CA5
ENST00000217169.8 [Q96CA5-1]
ENST00000342412.10 [Q96CA5-2]