NHLH2 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of NHLH2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	94%	448.31	2484 / 2642	16%	0.42	113 / 705
skin	71%	138.16	1277 / 1809	3%	0.10	13 / 472
esophagus	38%	164.95	555 / 1445	21%	0.87	39 / 183
prostate	40%	40.50	97 / 245	2%	0.03	8 / 502
tonsil	0%	0	0 / 0	38%	1.20	17 / 45
uterus	2%	2.92	3 / 170	28%	1.06	128 / 459
lung	17%	20.02	96 / 578	10%	0.35	114 / 1155
bladder	0%	0	0 / 21	13%	0.51	68 / 504
muscle	11%	22.12	92 / 803	0%	0	0 / 0
stomach	1%	0.71	5 / 359	5%	0.13	13 / 286
breast	2%	1.09	8 / 459	3%	0.14	33 / 1118
pancreas	0%	0	0 / 328	4%	0.26	7 / 178
intestine	0%	0	0 / 966	4%	0.12	20 / 527
thymus	0%	0	0 / 653	2%	0.09	15 / 605
liver	0%	0	0 / 226	2%	0.05	7 / 406
adrenal gland	0%	0.62	1 / 258	1%	0.02	3 / 230
eye	0%	0	0 / 0	1%	0.02	1 / 80
adipose	0%	0.23	3 / 1204	0%	0	0 / 0
ovary	0%	0	0 / 180	0%	0.00	1 / 430
kidney	0%	0	0 / 89	0%	0.01	2 / 901
blood vessel	0%	0.09	1 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0021888	Biological process	hypothalamus gonadotrophin-releasing hormone neuron development
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0060179	Biological process	male mating behavior
GO_0042698	Biological process	ovulation cycle
GO_0007422	Biological process	peripheral nervous system development
GO_0021535	Biological process	cell migration in hindbrain
GO_0007417	Biological process	central nervous system development
GO_0008584	Biological process	male gonad development
GO_0006915	Biological process	apoptotic process
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0000785	Cellular component	chromatin
GO_0005667	Cellular component	transcription regulator complex
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0046983	Molecular function	protein dimerization activity
GO_0005515	Molecular function	protein binding

Gene name	NHLH2
Protein name	Nescient helix-loop-helix 2 Helix-loop-helix protein 2 (HEN-2) (Class A basic helix-loop-helix protein 34) (bHLHa34) (Nescient helix loop helix 2) (NSCL-2)
Synonyms	HEN2 BHLHA34 KIAA0490
Description	FUNCTION: Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3'. Involved in regulating energy expenditure, body mass, voluntary physical activity, mating behavior and reproductive longevity, acting through the hypothalamic-pituitary-gonadal axis. Acts as a transcriptional activator of target genes, including NDN, PCSK1, MC4R (By similarity). Is also a transcriptional activator of KISS1 . May act centrally to regulate function of both white and brown adipose tissue. Together with NHLH1, required to maintain migration and survival of cells in the anterior extramural migration stream (aes), which forms the precerebellar nuclei. Also, in concert with NHLH1, may determine fate of gonadotropin releasing hormone-1 (GnRH-1) neurons. .
Accessions	Q02577 ENST00000369506.1 ENST00000429731.1 ENST00000320238.3 A6PVY9

NHLH2 report