MDM2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	16 studies	34% ± 15%	Explore
macrophage	11 studies	21% ± 6%	Explore
endothelial cell	9 studies	28% ± 9%	Explore
oligodendrocyte	9 studies	26% ± 9%	Explore
epithelial cell	8 studies	37% ± 17%	Explore
microglial cell	8 studies	24% ± 8%	Explore
myeloid cell	7 studies	26% ± 11%	Explore
classical monocyte	6 studies	23% ± 6%	Explore
non-classical monocyte	6 studies	23% ± 6%	Explore
basal cell	6 studies	30% ± 7%	Explore
adipocyte	6 studies	25% ± 7%	Explore
fibroblast	6 studies	20% ± 7%	Explore
type I pneumocyte	6 studies	21% ± 4%	Explore
astrocyte	6 studies	29% ± 11%	Explore
monocyte	5 studies	20% ± 1%	Explore
natural killer cell	5 studies	17% ± 1%	Explore
abnormal cell	5 studies	26% ± 15%	Explore
pericyte	5 studies	21% ± 6%	Explore
smooth muscle cell	5 studies	16% ± 0%	Explore
deuterosomal cell	4 studies	36% ± 10%	Explore
GABAergic neuron	4 studies	39% ± 13%	Explore
mast cell	4 studies	25% ± 13%	Explore
club cell	4 studies	27% ± 5%	Explore
glutamatergic neuron	4 studies	44% ± 16%	Explore
oligodendrocyte precursor cell	4 studies	28% ± 9%	Explore
alveolar macrophage	4 studies	29% ± 8%	Explore
goblet cell	4 studies	26% ± 11%	Explore
plasma cell	3 studies	33% ± 15%	Explore
plasmablast	3 studies	31% ± 10%	Explore
B cell	3 studies	23% ± 9%	Explore
pro-B cell	3 studies	39% ± 10%	Explore
hepatocyte	3 studies	49% ± 30%	Explore
dendritic cell	3 studies	21% ± 4%	Explore
endothelial cell of lymphatic vessel	3 studies	19% ± 5%	Explore
type II pneumocyte	3 studies	21% ± 2%	Explore
interneuron	3 studies	40% ± 20%	Explore
neuron	3 studies	26% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	7 studies	33% ± 14%	Explore
lung	6 studies	30% ± 11%	Explore
peripheral blood	3 studies	29% ± 8%	Explore
liver	3 studies	31% ± 20%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2845.49	1445 / 1445	100%	26.85	183 / 183
lung	100%	4931.06	578 / 578	100%	19.80	1154 / 1155
breast	100%	4485.42	459 / 459	100%	22.90	1116 / 1118
prostate	100%	4003.97	245 / 245	100%	14.00	500 / 502
thymus	100%	3304.45	652 / 653	100%	18.77	603 / 605
brain	100%	2353.12	2630 / 2642	100%	28.85	704 / 705
bladder	100%	3131.62	21 / 21	99%	27.80	498 / 504
uterus	100%	2889.31	170 / 170	98%	19.76	452 / 459
liver	100%	3867.77	226 / 226	98%	13.93	399 / 406
pancreas	100%	2996.33	327 / 328	98%	12.66	175 / 178
adrenal gland	100%	4420.84	258 / 258	98%	11.50	225 / 230
kidney	100%	2689.48	89 / 89	97%	21.17	877 / 901
stomach	100%	2465.45	359 / 359	97%	18.16	276 / 286
intestine	100%	2585.08	966 / 966	96%	14.69	507 / 527
skin	100%	5708.88	1809 / 1809	96%	26.71	453 / 472
ovary	100%	3142.14	180 / 180	93%	9.01	401 / 430
adipose	100%	4779.94	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	21.42	29 / 29
spleen	100%	4335.28	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	24.45	45 / 45
ureter	0%	0	0 / 0	100%	9.21	1 / 1
blood vessel	100%	2812.61	1334 / 1335	0%	0	0 / 0
muscle	100%	3614.51	802 / 803	0%	0	0 / 0
heart	97%	1687.08	836 / 861	0%	0	0 / 0
peripheral blood	92%	4554.22	854 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	84%	13.31	67 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010468	Biological process	regulation of gene expression
GO_0016925	Biological process	protein sumoylation
GO_0001974	Biological process	blood vessel remodeling
GO_0046827	Biological process	positive regulation of protein export from nucleus
GO_0002027	Biological process	regulation of heart rate
GO_0003203	Biological process	endocardial cushion morphogenesis
GO_0045931	Biological process	positive regulation of mitotic cell cycle
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0051603	Biological process	proteolysis involved in protein catabolic process
GO_0007089	Biological process	traversing start control point of mitotic cell cycle
GO_0009410	Biological process	response to xenobiotic stimulus
GO_1904707	Biological process	positive regulation of vascular associated smooth muscle cell proliferation
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0051726	Biological process	regulation of cell cycle
GO_0070301	Biological process	cellular response to hydrogen peroxide
GO_1901797	Biological process	negative regulation of signal transduction by p53 class mediator
GO_0007049	Biological process	cell cycle
GO_0010039	Biological process	response to iron ion
GO_0010955	Biological process	negative regulation of protein processing
GO_0000209	Biological process	protein polyubiquitination
GO_0032026	Biological process	response to magnesium ion
GO_0032436	Biological process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0010628	Biological process	positive regulation of gene expression
GO_0051865	Biological process	protein autoubiquitination
GO_0051149	Biological process	positive regulation of muscle cell differentiation
GO_0003281	Biological process	ventricular septum development
GO_0071480	Biological process	cellular response to gamma radiation
GO_0042220	Biological process	response to cocaine
GO_0071375	Biological process	cellular response to peptide hormone stimulus
GO_1902254	Biological process	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO_0001568	Biological process	blood vessel development
GO_0006977	Biological process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO_0043518	Biological process	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO_1904754	Biological process	positive regulation of vascular associated smooth muscle cell migration
GO_0016567	Biological process	protein ubiquitination
GO_0060411	Biological process	cardiac septum morphogenesis
GO_0072717	Biological process	cellular response to actinomycin D
GO_0003181	Biological process	atrioventricular valve morphogenesis
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0071391	Biological process	cellular response to estrogen stimulus
GO_0031648	Biological process	protein destabilization
GO_0071363	Biological process	cellular response to growth factor stimulus
GO_1990785	Biological process	response to water-immersion restraint stress
GO_0003283	Biological process	atrial septum development
GO_0071312	Biological process	cellular response to alkaloid
GO_0010977	Biological process	negative regulation of neuron projection development
GO_0046677	Biological process	response to antibiotic
GO_0048545	Biological process	response to steroid hormone
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0045472	Biological process	response to ether
GO_0009636	Biological process	response to toxic substance
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0042176	Biological process	regulation of protein catabolic process
GO_0072537	Biological process	fibroblast activation
GO_0045184	Biological process	establishment of protein localization
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0071301	Biological process	cellular response to vitamin B1
GO_0071494	Biological process	cellular response to UV-C
GO_0065003	Biological process	protein-containing complex assembly
GO_1904404	Biological process	response to formaldehyde
GO_1990000	Biological process	amyloid fibril formation
GO_0034504	Biological process	protein localization to nucleus
GO_0006915	Biological process	apoptotic process
GO_0071456	Biological process	cellular response to hypoxia
GO_0005634	Cellular component	nucleus
GO_0005730	Cellular component	nucleolus
GO_0005654	Cellular component	nucleoplasm
GO_0017053	Cellular component	transcription repressor complex
GO_0016604	Cellular component	nuclear body
GO_0005886	Cellular component	plasma membrane
GO_0030666	Cellular component	endocytic vesicle membrane
GO_0032991	Cellular component	protein-containing complex
GO_0005737	Cellular component	cytoplasm
GO_0005829	Cellular component	cytosol
GO_0019789	Molecular function	SUMO transferase activity
GO_0042802	Molecular function	identical protein binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0033612	Molecular function	receptor serine/threonine kinase binding
GO_0008270	Molecular function	zinc ion binding
GO_0042975	Molecular function	peroxisome proliferator activated receptor binding
GO_0016874	Molecular function	ligase activity
GO_0043021	Molecular function	ribonucleoprotein complex binding
GO_0061663	Molecular function	NEDD8 ligase activity
GO_0043130	Molecular function	ubiquitin binding
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0019899	Molecular function	enzyme binding
GO_0019904	Molecular function	protein domain specific binding
GO_0008097	Molecular function	5S rRNA binding
GO_0002039	Molecular function	p53 binding
GO_0005515	Molecular function	protein binding
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0097718	Molecular function	disordered domain specific binding

IV. Literature review

[source]

Gene name	MDM2
Protein name	MDM2 variant FB55 p53 binding protein p53-binding protein MDM2 proto-oncogene (p53-binding protein) MDM2 variant FB29 MDM2 variant FB30 MDM2 protein MDM2 proto-oncogene (p53 binding protein) E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) MDM2 proto-oncogene MDM2 protein (MDM2 proto-oncogene) MDM2 variant FB26 MDM2 isoform N1_40 protein MDM2 variant FB28 HDM2-HD1 protein (p53 binding protein) E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) MDM2 isoform KB9 protein MDM2 protein (MDM2 proto-oncogene) (MDM2 variant FB25) MDM2 protein (p53-binding protein) E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) Mdm2
Synonyms	isoform N1_40 hCG_2014981 mdm2 HDM2 KB9
Description	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome . Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation . Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis . Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis . .
Accessions	ENST00000665020.1 ENST00000350057.9 A0A0C4DFR5 D0EKL1 ENST00000481186.6 ENST00000542502.5 ENST00000536089.5 ENST00000540352.5 Q8WYJ3 J3KN53 Q8NDW0 Q96DS1 ENST00000523991.5 ENST00000496959.5 E5RJQ0 A0A0A8K9I1 F5GZC3 E5RHE2 Q8TE47 A0A0A8K9H7 ENST00000544561.6 ENST00000258149.11 [Q00987-11] A0A0A8KB78 A0A0A8K9G9 Q8TE46 A0A0A8KB88 Q9H4C4 ENST00000666617.1 Q8NDV9 A0A0A8KBA1 A0A0A8K9A4 A0A0A8K992 A0A0A8K9A1 ENST00000393412.7 A8WFP2 Q96DS3 ENST00000537182.5 Q8NDW2 ENST00000258148.11 ENST00000539479.6 [Q00987-1] ENST00000671567.1 ENST00000393416.7 Q546E6 A0A0A8KB75 E7EMW5 ENST00000299252.8 [Q00987-5] A0A0A8KA17 Q96DS5 Q96DS2 F6UXB6 ENST00000393415.7 E7EPE2 J3QST1 ENST00000360430.6 [Q00987-2] A0A1B0GXJ6 ENST00000546048.5 Q8NDW1 A0A0A8KB92 A7UKX8 A0A0A8KB67 A0A0A8KA06 ENST00000393413.7 [Q00987-4] A0A0A8KB97 Q96DS4 A0A0A8K986 ENST00000543323.5 ENST00000393410.5 Q9H4C3 ENST00000311420.13 A0A0A8K982 Q9H4C2 F5H1M7 G3XA89 ENST00000348801.7 ENST00000478070.2 F5GWH7 A0A0A8K9H4 ENST00000545204.2 A0A0A8K972 Q00987 A0A0A8KA03 A0A0A8K975 ENST00000393417.8 Q9H4C5 F5H4Q8 A0A0A8KB70 Q96DS0 F5GZB0 A0A0A8K978 A0A0A8K9G1 ENST00000517852.5

MDM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review