CIDEB report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CIDEB at tissue level.

III. Associated gene sets

GO_0120009Biological processintermembrane lipid transfer
GO_0034379Biological processvery-low-density lipoprotein particle assembly
GO_0160077Biological processlipid droplet fusion
GO_0038183Biological processbile acid signaling pathway
GO_0031667Biological processresponse to nutrient levels
GO_0090207Biological processregulation of triglyceride metabolic process
GO_0042981Biological processregulation of apoptotic process
GO_0019915Biological processlipid storage
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0097194Biological processexecution phase of apoptosis
GO_0006915Biological processapoptotic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0090110Biological processCOPII-coated vesicle cargo loading
GO_0005811Cellular componentlipid droplet
GO_0030137Cellular componentCOPI-coated vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0030127Cellular componentCOPII vesicle coat
GO_0005794Cellular componentGolgi apparatus
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0060090Molecular functionmolecular adaptor activity
GO_0042802Molecular functionidentical protein binding
GO_0120013Molecular functionlipid transfer activity
GO_0070300Molecular functionphosphatidic acid binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCIDEB
Protein nameCell death inducing DFFA like effector b
Lipid transferase CIDEB (Cell death activator CIDE-B) (Cell death-inducing DFFA-like effector B)
Synonyms
DescriptionFUNCTION: Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion . Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage . Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity). Promotes lipid exchange and lipid droplet fusion in both small and large lipid droplet-containing hepatocytes (By similarity). In addition to its role in lipid droplet fusion, also involved in cytoplasmic vesicle biogenesis and transport (By similarity). Required for very-low-density lipoprotein (VLDL) lipidation and maturation (By similarity). Probably involved in the biogenesis of VLDL transport vesicles by forming a COPII vesicle coat and facilitating the formation of endoplasmic reticulum-derived large vesicles (By similarity). Also involved in sterol-regulated export of the SCAP-SREBP complex, composed of SCAP, SREBF1/SREBP1 and SREBF2/SREBP2, by promoting loading of SCAP-SREBP into COPII vesicles (By similarity). May also activate apoptosis . .; FUNCTION: (Microbial infection) Involved in Hepatatis C virus (HCV) assembly and required for HCV entry into hepatocytes. .

AccessionsENST00000642223.1
ENST00000554411.6
G3V4E2
ENST00000556756.1
ENST00000336557.9
ENST00000644672.1
Q9UHD4
ENST00000258807.5
ENST00000644519.1