TRAF1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRAF1 at tissue level.

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_2001236Biological processregulation of extrinsic apoptotic signaling pathway
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0065003Biological processprotein-containing complex assembly
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0098802Cellular componentplasma membrane signaling receptor complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0031996Molecular functionthioesterase binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTRAF1
Protein nameTNF receptor associated factor 1/ALK receptor tyrosine kinase fusion protein
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Synonymsfusion
ALK
EBI6
DescriptionFUNCTION: Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. .

AccessionsENST00000373887.8 [Q13077-1]
ENST00000540010.1 [Q13077-1]
Q13077
ENST00000546084.5 [Q13077-2]
A0A6G8IRL2