DPP8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0006955Biological processimmune response
GO_0006508Biological processproteolysis
GO_0043069Biological processnegative regulation of programmed cell death
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0008236Molecular functionserine-type peptidase activity
GO_0008239Molecular functiondipeptidyl-peptidase activity
GO_0005515Molecular functionprotein binding
GO_0004177Molecular functionaminopeptidase activity

IV. Literature review

[source]
Gene nameDPP8
Protein nameDipeptidyl peptidase 8
Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 1) (DPRP-1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8)
dipeptidyl-peptidase IV (EC 3.4.14.5)
SynonymsMSTP097
MSTP135
MSTP141
DPRP1
DescriptionFUNCTION: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 . Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 . Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation . The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity). .

AccessionsENST00000300141.11 [Q6V1X1-3]
H0YK36
ENST00000558786.5
ENST00000558529.1
ENST00000395652.7
ENST00000559233.5 [Q6V1X1-1]
H3BQ40
H0YKA2
ENST00000558559.1
ENST00000341861.9 [Q6V1X1-1]
H3BNM2
ENST00000321147.10 [Q6V1X1-2]
ENST00000559526.5
H0YN53
J3KPT0
ENST00000560436.1
H0YMV1
ENST00000358939.8 [Q6V1X1-4]
ENST00000560665.1
Q6V1X1