Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 15 studies | 26% ± 6% | |
| astrocyte | 10 studies | 33% ± 15% | |
| oligodendrocyte | 8 studies | 26% ± 8% | |
| glutamatergic neuron | 7 studies | 41% ± 24% | |
| GABAergic neuron | 7 studies | 36% ± 21% | |
| microglial cell | 6 studies | 26% ± 7% | |
| epithelial cell | 6 studies | 29% ± 9% | |
| macrophage | 6 studies | 27% ± 6% | |
| natural killer cell | 5 studies | 20% ± 2% | |
| CD16-positive, CD56-dim natural killer cell, human | 5 studies | 17% ± 1% | |
| neuron | 5 studies | 26% ± 10% | |
| dendritic cell | 5 studies | 22% ± 11% | |
| myeloid cell | 4 studies | 22% ± 3% | |
| fibroblast | 4 studies | 19% ± 3% | |
| adipocyte | 4 studies | 19% ± 3% | |
| ciliated cell | 4 studies | 20% ± 3% | |
| lymphocyte | 4 studies | 23% ± 7% | |
| oligodendrocyte precursor cell | 4 studies | 30% ± 8% | |
| endothelial cell of lymphatic vessel | 4 studies | 22% ± 2% | |
| interneuron | 4 studies | 44% ± 23% | |
| classical monocyte | 3 studies | 23% ± 5% | |
| hematopoietic precursor cell | 3 studies | 21% ± 3% | |
| non-classical monocyte | 3 studies | 25% ± 9% | |
| B cell | 3 studies | 17% ± 1% | |
| alveolar macrophage | 3 studies | 22% ± 6% | |
| monocyte | 3 studies | 21% ± 3% | |
| basal cell | 3 studies | 26% ± 9% | |
| goblet cell | 3 studies | 24% ± 11% | |
| transit amplifying cell | 3 studies | 28% ± 14% | |
| mast cell | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 3221.83 | 2642 / 2642 | 100% | 25.89 | 705 / 705 |
| esophagus | 100% | 2643.35 | 1445 / 1445 | 100% | 18.41 | 183 / 183 |
| lung | 100% | 2583.43 | 578 / 578 | 100% | 14.23 | 1155 / 1155 |
| ovary | 100% | 2979.02 | 180 / 180 | 100% | 10.19 | 430 / 430 |
| breast | 100% | 3062.49 | 459 / 459 | 100% | 18.35 | 1114 / 1118 |
| prostate | 100% | 2596.35 | 245 / 245 | 100% | 13.64 | 500 / 502 |
| thymus | 100% | 2997.42 | 653 / 653 | 100% | 15.34 | 602 / 605 |
| pancreas | 100% | 1319.49 | 327 / 328 | 99% | 13.17 | 176 / 178 |
| kidney | 100% | 1956.55 | 89 / 89 | 99% | 14.73 | 888 / 901 |
| bladder | 100% | 3026.05 | 21 / 21 | 98% | 11.29 | 494 / 504 |
| stomach | 100% | 1968.15 | 359 / 359 | 98% | 13.53 | 280 / 286 |
| intestine | 100% | 3008.68 | 966 / 966 | 98% | 12.08 | 515 / 527 |
| uterus | 100% | 3147.69 | 170 / 170 | 98% | 11.97 | 448 / 459 |
| adrenal gland | 100% | 3135.96 | 258 / 258 | 97% | 13.39 | 222 / 230 |
| skin | 100% | 3076.49 | 1808 / 1809 | 95% | 15.44 | 449 / 472 |
| liver | 100% | 986.58 | 225 / 226 | 80% | 5.52 | 323 / 406 |
| adipose | 100% | 3142.73 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3077.66 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 10.57 | 29 / 29 |
| muscle | 100% | 3891.07 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 3136.96 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.40 | 1 / 1 |
| heart | 98% | 2110.13 | 844 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 12.49 | 43 / 45 |
| peripheral blood | 88% | 1693.81 | 815 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 85% | 8.18 | 68 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006915 | Biological process | apoptotic process |
| GO_0006955 | Biological process | immune response |
| GO_0006508 | Biological process | proteolysis |
| GO_0043069 | Biological process | negative regulation of programmed cell death |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0008236 | Molecular function | serine-type peptidase activity |
| GO_0008239 | Molecular function | dipeptidyl-peptidase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0004177 | Molecular function | aminopeptidase activity |
| Gene name | DPP8 |
| Protein name | Dipeptidyl peptidase 8 Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 1) (DPRP-1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8) dipeptidyl-peptidase IV (EC 3.4.14.5) |
| Synonyms | MSTP097 MSTP135 MSTP141 DPRP1 |
| Description | FUNCTION: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 . Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 . Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation . The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity). . |
| Accessions | ENST00000300141.11 [Q6V1X1-3] H0YK36 ENST00000558786.5 ENST00000558529.1 ENST00000395652.7 ENST00000559233.5 [Q6V1X1-1] H3BQ40 H0YKA2 ENST00000558559.1 ENST00000341861.9 [Q6V1X1-1] H3BNM2 ENST00000321147.10 [Q6V1X1-2] ENST00000559526.5 H0YN53 J3KPT0 ENST00000560436.1 H0YMV1 ENST00000358939.8 [Q6V1X1-4] ENST00000560665.1 Q6V1X1 |