CASP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097190Biological processapoptotic signaling pathway
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0071260Biological processcellular response to mechanical stimulus
GO_0006974Biological processDNA damage response
GO_0016485Biological processprotein processing
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0001554Biological processluteolysis
GO_0006977Biological processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO_0097194Biological processexecution phase of apoptosis
GO_0006915Biological processapoptotic process
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0043065Biological processpositive regulation of apoptotic process
GO_0035234Biological processectopic germ cell programmed cell death
GO_0003407Biological processneural retina development
GO_0005730Cellular componentnucleolus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1905369Cellular componentendopeptidase complex
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0019904Molecular functionprotein domain specific binding
GO_0042802Molecular functionidentical protein binding
GO_0097200Molecular functioncysteine-type endopeptidase activity involved in execution phase of apoptosis
GO_0097199Molecular functioncysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCASP2
Protein nameCaspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
Caspase 2 apoptosis-related cysteine peptidase isoform 1
Caspase 2 apoptosis-related cysteine peptidase isoform 2
Caspase 2
SynonymsICH1
NEDD2
DescriptionFUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival . Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress . .

AccessionsP42575
A0A087WYM1
A0A0S2Z3H1
ENST00000619992.4
C9JRR9
ENST00000350623.7
A0A0S2Z3I0
ENST00000310447.10 [P42575-1]
ENST00000392925.6