NOC2L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034644Biological processcellular response to UV
GO_0002903Biological processnegative regulation of B cell apoptotic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0042273Biological processribosomal large subunit biogenesis
GO_0006915Biological processapoptotic process
GO_2001243Biological processnegative regulation of intrinsic apoptotic signaling pathway
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0005730Cellular componentnucleolus
GO_0030690Cellular componentNoc1p-Noc2p complex
GO_0005654Cellular componentnucleoplasm
GO_0030691Cellular componentNoc2p-Noc3p complex
GO_0005829Cellular componentcytosol
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0003723Molecular functionRNA binding
GO_0031491Molecular functionnucleosome binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNOC2L
Protein nameNucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor)
SynonymsNIR
DescriptionFUNCTION: Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. .

AccessionsENST00000327044.7
Q9Y3T9