Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 6 studies | 20% ± 5% | |
plasmablast | 5 studies | 29% ± 13% | |
natural killer cell | 5 studies | 32% ± 10% | |
deuterosomal cell | 4 studies | 35% ± 8% | |
hematopoietic precursor cell | 4 studies | 23% ± 4% | |
epithelial cell | 4 studies | 25% ± 9% | |
CD8-positive, alpha-beta T cell | 4 studies | 25% ± 6% | |
T cell | 3 studies | 23% ± 2% | |
abnormal cell | 3 studies | 26% ± 9% | |
neural crest cell | 3 studies | 26% ± 7% | |
granulocyte monocyte progenitor cell | 3 studies | 23% ± 5% | |
transit amplifying cell | 3 studies | 45% ± 18% |
Insufficient scRNA-seq data for expression of HELLS at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
uterus | 99% | 473.65 | 168 / 170 | 98% | 14.21 | 449 / 459 |
ovary | 99% | 473.76 | 179 / 180 | 91% | 5.94 | 393 / 430 |
skin | 99% | 830.97 | 1798 / 1809 | 86% | 5.32 | 407 / 472 |
bladder | 90% | 289.62 | 19 / 21 | 95% | 8.46 | 479 / 504 |
lung | 94% | 316.00 | 544 / 578 | 91% | 8.02 | 1046 / 1155 |
stomach | 86% | 295.28 | 308 / 359 | 97% | 9.66 | 277 / 286 |
breast | 86% | 246.17 | 394 / 459 | 92% | 6.69 | 1034 / 1118 |
esophagus | 75% | 417.85 | 1084 / 1445 | 100% | 15.52 | 183 / 183 |
intestine | 76% | 358.16 | 737 / 966 | 96% | 8.85 | 504 / 527 |
thymus | 92% | 203.08 | 604 / 653 | 59% | 3.07 | 356 / 605 |
pancreas | 66% | 107.03 | 216 / 328 | 82% | 3.69 | 146 / 178 |
kidney | 96% | 335.11 | 85 / 89 | 51% | 1.89 | 456 / 901 |
adrenal gland | 91% | 194.33 | 236 / 258 | 54% | 2.39 | 124 / 230 |
prostate | 99% | 405.80 | 242 / 245 | 27% | 0.89 | 136 / 502 |
brain | 70% | 288.62 | 1852 / 2642 | 45% | 2.07 | 315 / 705 |
lymph node | 0% | 0 | 0 / 0 | 100% | 15.16 | 29 / 29 |
spleen | 100% | 750.91 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 15.35 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.81 | 1 / 1 |
liver | 49% | 109.45 | 110 / 226 | 41% | 2.14 | 168 / 406 |
adipose | 83% | 159.67 | 997 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 60% | 96.17 | 798 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 47% | 1341.56 | 440 / 929 | 0% | 0 | 0 / 0 |
heart | 28% | 42.94 | 240 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 20% | 0.57 | 16 / 80 |
muscle | 3% | 3.34 | 22 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0001655 | Biological process | urogenital system development |
GO_0006346 | Biological process | DNA methylation-dependent heterochromatin formation |
GO_1990830 | Biological process | cellular response to leukemia inhibitory factor |
GO_0001822 | Biological process | kidney development |
GO_0044027 | Biological process | negative regulation of gene expression via chromosomal CpG island methylation |
GO_0051301 | Biological process | cell division |
GO_0046651 | Biological process | lymphocyte proliferation |
GO_0006915 | Biological process | apoptotic process |
GO_2001243 | Biological process | negative regulation of intrinsic apoptotic signaling pathway |
GO_0031508 | Biological process | pericentric heterochromatin formation |
GO_0000775 | Cellular component | chromosome, centromeric region |
GO_0005721 | Cellular component | pericentric heterochromatin |
GO_0005634 | Cellular component | nucleus |
GO_0004386 | Molecular function | helicase activity |
GO_0003682 | Molecular function | chromatin binding |
GO_0016787 | Molecular function | hydrolase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0140658 | Molecular function | ATP-dependent chromatin remodeler activity |
GO_0005515 | Molecular function | protein binding |
Gene name | HELLS |
Protein name | Helicase, lymphoid specific Lymphoid specific helicase variant9 Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) Helicase, lymphoid specific (Helicase, lymphoid-specific, isoform CRA_b) HELLS protein Helicase, lymphoid specific (Lymphoid specific helicase variant1) Helicase, lymphoid-specific, isoform CRA_d (Lymphoid-specific helicase) Lymphoid-specific helicase |
Synonyms | PASG Nbla10143 SMARCA6 hCG_39170 |
Description | FUNCTION: Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). . |
Accessions | ENST00000630929.3 Q0VGL2 ENST00000394045.6 [Q9NRZ9-5] ENST00000698830.1 [Q9NRZ9-8] Q76H82 ENST00000371332.8 ENST00000419900.5 ENST00000348459.10 [Q9NRZ9-1] ENST00000698800.1 [Q9NRZ9-7] ENST00000419900.6 [Q9NRZ9-2] ENST00000371327.3 ENST00000698799.1 [Q9NRZ9-6] Q9NRZ9 ENST00000698675.1 [Q9NRZ9-3] Q6I7N8 F6RPV8 ENST00000371332.9 [Q9NRZ9-9] ENST00000394036.6 ENST00000698673.1 A0A087WSW7 A0A0B4J1V9 A0A8V8TMK7 B1ALG6 |