HELLS report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HELLS at tissue level.

III. Associated gene sets

GO_0001655Biological processurogenital system development
GO_0006346Biological processDNA methylation-dependent heterochromatin formation
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0001822Biological processkidney development
GO_0044027Biological processnegative regulation of gene expression via chromosomal CpG island methylation
GO_0051301Biological processcell division
GO_0046651Biological processlymphocyte proliferation
GO_0006915Biological processapoptotic process
GO_2001243Biological processnegative regulation of intrinsic apoptotic signaling pathway
GO_0031508Biological processpericentric heterochromatin formation
GO_0000775Cellular componentchromosome, centromeric region
GO_0005721Cellular componentpericentric heterochromatin
GO_0005634Cellular componentnucleus
GO_0004386Molecular functionhelicase activity
GO_0003682Molecular functionchromatin binding
GO_0016787Molecular functionhydrolase activity
GO_0005524Molecular functionATP binding
GO_0140658Molecular functionATP-dependent chromatin remodeler activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHELLS
Protein nameHelicase, lymphoid specific
Lymphoid specific helicase variant9
Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)
Helicase, lymphoid specific (Helicase, lymphoid-specific, isoform CRA_b)
HELLS protein
Helicase, lymphoid specific (Lymphoid specific helicase variant1)
Helicase, lymphoid-specific, isoform CRA_d (Lymphoid-specific helicase)
Lymphoid-specific helicase
SynonymsPASG
Nbla10143
SMARCA6
hCG_39170
DescriptionFUNCTION: Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). .

AccessionsENST00000630929.3
Q0VGL2
ENST00000394045.6 [Q9NRZ9-5]
ENST00000698830.1 [Q9NRZ9-8]
Q76H82
ENST00000371332.8
ENST00000419900.5
ENST00000348459.10 [Q9NRZ9-1]
ENST00000698800.1 [Q9NRZ9-7]
ENST00000419900.6 [Q9NRZ9-2]
ENST00000371327.3
ENST00000698799.1 [Q9NRZ9-6]
Q9NRZ9
ENST00000698675.1 [Q9NRZ9-3]
Q6I7N8
F6RPV8
ENST00000371332.9 [Q9NRZ9-9]
ENST00000394036.6
ENST00000698673.1
A0A087WSW7
A0A0B4J1V9
A0A8V8TMK7
B1ALG6