PRKCB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014059Biological processregulation of dopamine secretion
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0033280Biological processresponse to vitamin D
GO_0009749Biological processresponse to glucose
GO_0045766Biological processpositive regulation of angiogenesis
GO_0007207Biological processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0050853Biological processB cell receptor signaling pathway
GO_0050861Biological processpositive regulation of B cell receptor signaling pathway
GO_0007077Biological processmitotic nuclear membrane disassembly
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0010827Biological processregulation of glucose transmembrane transport
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0045471Biological processresponse to ethanol
GO_0043687Biological processpost-translational protein modification
GO_0006338Biological processchromatin remodeling
GO_0032024Biological processpositive regulation of insulin secretion
GO_0042488Biological processpositive regulation of odontogenesis of dentin-containing tooth
GO_0002250Biological processadaptive immune response
GO_0035556Biological processintracellular signal transduction
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0042113Biological processB cell activation
GO_0099171Biological processpresynaptic modulation of chemical synaptic transmission
GO_0010829Biological processnegative regulation of glucose transmembrane transport
GO_0006915Biological processapoptotic process
GO_0042953Biological processlipoprotein transport
GO_0030949Biological processpositive regulation of vascular endothelial growth factor receptor signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0006816Biological processcalcium ion transport
GO_0040008Biological processregulation of growth
GO_0018894Biological processdibenzo-p-dioxin metabolic process
GO_2000300Biological processregulation of synaptic vesicle exocytosis
GO_0071322Biological processcellular response to carbohydrate stimulus
GO_0031526Cellular componentbrush border membrane
GO_0005886Cellular componentplasma membrane
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0044305Cellular componentcalyx of Held
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0099523Cellular componentpresynaptic cytosol
GO_0008091Cellular componentspectrin
GO_0005634Cellular componentnucleus
GO_0005080Molecular functionprotein kinase C binding
GO_0035403Molecular functionhistone H3T6 kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_0005246Molecular functioncalcium channel regulator activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0004697Molecular functiondiacylglycerol-dependent serine/threonine kinase activity
GO_0005515Molecular functionprotein binding
GO_0030374Molecular functionnuclear receptor coactivator activity

IV. Literature review

[source]
Gene namePRKCB
Protein nameProtein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)
Protein kinase C beta
SynonymsPKCB
PRKCB1
DescriptionFUNCTION: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity . Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A . In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 . Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription . Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 . .

AccessionsENST00000643927.1 [P05771-2]
ENST00000472066.1
ENST00000466124.1
ENST00000498739.1
I3L1Z0
ENST00000321728.12 [P05771-1]
I3L148
H3BV73
P05771