Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 96% | 14251.34 | 2543 / 2642 | 96% | 24.50 | 679 / 705 |
lung | 95% | 2239.18 | 548 / 578 | 72% | 4.88 | 835 / 1155 |
intestine | 84% | 3042.89 | 809 / 966 | 35% | 2.05 | 186 / 527 |
bladder | 76% | 1577.14 | 16 / 21 | 37% | 2.12 | 185 / 504 |
lymph node | 0% | 0 | 0 / 0 | 100% | 48.23 | 29 / 29 |
spleen | 100% | 10697.21 | 241 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 13661.43 | 921 / 929 | 0% | 0 | 0 / 0 |
prostate | 42% | 905.69 | 103 / 245 | 56% | 2.81 | 281 / 502 |
stomach | 36% | 1279.32 | 128 / 359 | 51% | 3.89 | 146 / 286 |
skin | 18% | 260.98 | 329 / 1809 | 53% | 5.99 | 252 / 472 |
tonsil | 0% | 0 | 0 / 0 | 67% | 4.67 | 30 / 45 |
kidney | 10% | 208.80 | 9 / 89 | 55% | 2.83 | 496 / 901 |
esophagus | 18% | 329.73 | 255 / 1445 | 44% | 2.50 | 81 / 183 |
thymus | 6% | 177.24 | 37 / 653 | 44% | 6.23 | 264 / 605 |
pancreas | 0% | 3.68 | 1 / 328 | 48% | 3.50 | 85 / 178 |
breast | 1% | 16.89 | 5 / 459 | 46% | 2.66 | 511 / 1118 |
uterus | 13% | 213.27 | 22 / 170 | 34% | 1.97 | 155 / 459 |
ovary | 0% | 0 | 0 / 180 | 28% | 1.29 | 122 / 430 |
blood vessel | 26% | 544.95 | 345 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 23% | 1.58 | 18 / 80 |
adrenal gland | 0% | 0 | 0 / 258 | 18% | 1.38 | 42 / 230 |
liver | 1% | 12.78 | 2 / 226 | 12% | 0.67 | 50 / 406 |
adipose | 10% | 157.33 | 117 / 1204 | 0% | 0 | 0 / 0 |
heart | 0% | 2.69 | 2 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0014059 | Biological process | regulation of dopamine secretion |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0033280 | Biological process | response to vitamin D |
GO_0009749 | Biological process | response to glucose |
GO_0045766 | Biological process | positive regulation of angiogenesis |
GO_0007207 | Biological process | phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0007165 | Biological process | signal transduction |
GO_0050853 | Biological process | B cell receptor signaling pathway |
GO_0050861 | Biological process | positive regulation of B cell receptor signaling pathway |
GO_0007077 | Biological process | mitotic nuclear membrane disassembly |
GO_0006874 | Biological process | intracellular calcium ion homeostasis |
GO_0010827 | Biological process | regulation of glucose transmembrane transport |
GO_0046627 | Biological process | negative regulation of insulin receptor signaling pathway |
GO_0045471 | Biological process | response to ethanol |
GO_0043687 | Biological process | post-translational protein modification |
GO_0006338 | Biological process | chromatin remodeling |
GO_0032024 | Biological process | positive regulation of insulin secretion |
GO_0042488 | Biological process | positive regulation of odontogenesis of dentin-containing tooth |
GO_0002250 | Biological process | adaptive immune response |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0042113 | Biological process | B cell activation |
GO_0099171 | Biological process | presynaptic modulation of chemical synaptic transmission |
GO_0010829 | Biological process | negative regulation of glucose transmembrane transport |
GO_0006915 | Biological process | apoptotic process |
GO_0042953 | Biological process | lipoprotein transport |
GO_0030949 | Biological process | positive regulation of vascular endothelial growth factor receptor signaling pathway |
GO_0006468 | Biological process | protein phosphorylation |
GO_0009410 | Biological process | response to xenobiotic stimulus |
GO_0006816 | Biological process | calcium ion transport |
GO_0040008 | Biological process | regulation of growth |
GO_0018894 | Biological process | dibenzo-p-dioxin metabolic process |
GO_2000300 | Biological process | regulation of synaptic vesicle exocytosis |
GO_0071322 | Biological process | cellular response to carbohydrate stimulus |
GO_0031526 | Cellular component | brush border membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0005813 | Cellular component | centrosome |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0044305 | Cellular component | calyx of Held |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0099523 | Cellular component | presynaptic cytosol |
GO_0008091 | Cellular component | spectrin |
GO_0005634 | Cellular component | nucleus |
GO_0005080 | Molecular function | protein kinase C binding |
GO_0035403 | Molecular function | histone H3T6 kinase activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0042393 | Molecular function | histone binding |
GO_0003682 | Molecular function | chromatin binding |
GO_0005246 | Molecular function | calcium channel regulator activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0008270 | Molecular function | zinc ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0050681 | Molecular function | nuclear androgen receptor binding |
GO_0004697 | Molecular function | diacylglycerol-dependent serine/threonine kinase activity |
GO_0005515 | Molecular function | protein binding |
GO_0030374 | Molecular function | nuclear receptor coactivator activity |
Gene name | PRKCB |
Protein name | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) Protein kinase C beta |
Synonyms | PKCB PRKCB1 |
Description | FUNCTION: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity . Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A . In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 . Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription . Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 . . |
Accessions | ENST00000643927.1 [P05771-2] ENST00000472066.1 ENST00000466124.1 ENST00000498739.1 I3L1Z0 ENST00000321728.12 [P05771-1] I3L148 H3BV73 P05771 |