Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 20 studies | 35% ± 16% | |
astrocyte | 19 studies | 60% ± 17% | |
oligodendrocyte | 17 studies | 76% ± 24% | |
oligodendrocyte precursor cell | 15 studies | 66% ± 19% | |
glutamatergic neuron | 9 studies | 45% ± 25% | |
microglial cell | 9 studies | 36% ± 14% | |
pericyte | 8 studies | 35% ± 15% | |
adipocyte | 8 studies | 29% ± 9% | |
GABAergic neuron | 7 studies | 49% ± 15% | |
neuron | 7 studies | 39% ± 21% | |
smooth muscle cell | 7 studies | 24% ± 9% | |
interneuron | 6 studies | 34% ± 15% | |
ciliated cell | 6 studies | 28% ± 13% | |
Mueller cell | 6 studies | 59% ± 30% | |
epithelial cell | 5 studies | 34% ± 11% | |
monocyte | 5 studies | 21% ± 7% | |
fibroblast | 5 studies | 26% ± 8% | |
granule cell | 4 studies | 28% ± 7% | |
macrophage | 4 studies | 34% ± 7% | |
amacrine cell | 4 studies | 38% ± 13% | |
retinal cone cell | 4 studies | 36% ± 9% | |
retinal rod cell | 4 studies | 33% ± 7% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 61% ± 13% | |
progenitor cell | 3 studies | 33% ± 6% | |
GABAergic amacrine cell | 3 studies | 32% ± 9% | |
glycinergic amacrine cell | 3 studies | 37% ± 4% | |
retinal ganglion cell | 3 studies | 36% ± 15% | |
endothelial cell of vascular tree | 3 studies | 27% ± 12% | |
hepatocyte | 3 studies | 58% ± 18% | |
ependymal cell | 3 studies | 49% ± 12% | |
capillary endothelial cell | 3 studies | 27% ± 5% | |
club cell | 3 studies | 23% ± 7% | |
type I pneumocyte | 3 studies | 20% ± 5% | |
basal cell | 3 studies | 27% ± 8% | |
mesothelial cell | 3 studies | 29% ± 2% | |
dendritic cell | 3 studies | 22% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 5490.96 | 2642 / 2642 | 100% | 75.18 | 703 / 705 |
esophagus | 100% | 1745.90 | 1442 / 1445 | 99% | 17.50 | 182 / 183 |
skin | 99% | 2932.77 | 1790 / 1809 | 99% | 34.64 | 465 / 472 |
prostate | 100% | 1201.71 | 244 / 245 | 97% | 10.59 | 489 / 502 |
thymus | 99% | 1517.13 | 648 / 653 | 94% | 9.98 | 568 / 605 |
intestine | 100% | 1520.98 | 964 / 966 | 93% | 8.98 | 489 / 527 |
stomach | 95% | 1035.22 | 342 / 359 | 95% | 10.51 | 272 / 286 |
breast | 99% | 1777.20 | 455 / 459 | 90% | 10.52 | 1008 / 1118 |
uterus | 99% | 1473.92 | 169 / 170 | 89% | 9.94 | 409 / 459 |
bladder | 100% | 1705.43 | 21 / 21 | 88% | 9.96 | 445 / 504 |
lung | 97% | 1121.36 | 560 / 578 | 88% | 10.10 | 1013 / 1155 |
liver | 97% | 1752.42 | 219 / 226 | 88% | 10.16 | 356 / 406 |
pancreas | 96% | 1052.15 | 315 / 328 | 82% | 5.84 | 146 / 178 |
adrenal gland | 100% | 4430.45 | 258 / 258 | 45% | 5.52 | 104 / 230 |
kidney | 82% | 691.81 | 73 / 89 | 63% | 4.68 | 565 / 901 |
ovary | 99% | 1240.76 | 179 / 180 | 41% | 2.93 | 175 / 430 |
eye | 0% | 0 | 0 / 0 | 100% | 41.91 | 80 / 80 |
tonsil | 0% | 0 | 0 / 0 | 100% | 14.33 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.02 | 1 / 1 |
adipose | 99% | 1470.98 | 1190 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 97% | 1285.64 | 1300 / 1335 | 0% | 0 | 0 / 0 |
muscle | 74% | 643.63 | 592 / 803 | 0% | 0 | 0 / 0 |
spleen | 61% | 429.82 | 146 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 58% | 688.13 | 537 / 929 | 0% | 0 | 0 / 0 |
heart | 54% | 380.26 | 469 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 52% | 6.17 | 15 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007165 | Biological process | signal transduction |
GO_0006915 | Biological process | apoptotic process |
GO_0009649 | Biological process | entrainment of circadian clock |
GO_0046328 | Biological process | regulation of JNK cascade |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_0043408 | Biological process | regulation of MAPK cascade |
GO_0002667 | Biological process | regulation of T cell anergy |
GO_0006470 | Biological process | protein dephosphorylation |
GO_0051898 | Biological process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_1900744 | Biological process | regulation of p38MAPK cascade |
GO_0005634 | Cellular component | nucleus |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005515 | Molecular function | protein binding |
GO_0017018 | Molecular function | myosin phosphatase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0004722 | Molecular function | protein serine/threonine phosphatase activity |
Gene name | PHLPP1 |
Protein name | PH domain and leucine rich repeat protein phosphatase 1 PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) |
Synonyms | PLEKHE1 SCOP KIAA0606 PHLPP |
Description | FUNCTION: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA . Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation . Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis . Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation . Inhibits cancer cell proliferation and may act as a tumor suppressor . Dephosphorylates RAF1 inhibiting its kinase activity . May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). . |
Accessions | O60346 K7EP91 ENST00000262719.10 [O60346-1] ENST00000591386.1 |