PHLPP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006915Biological processapoptotic process
GO_0009649Biological processentrainment of circadian clock
GO_0046328Biological processregulation of JNK cascade
GO_0042981Biological processregulation of apoptotic process
GO_0043408Biological processregulation of MAPK cascade
GO_0002667Biological processregulation of T cell anergy
GO_0006470Biological processprotein dephosphorylation
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1900744Biological processregulation of p38MAPK cascade
GO_0005634Cellular componentnucleus
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0017018Molecular functionmyosin phosphatase activity
GO_0046872Molecular functionmetal ion binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity

IV. Literature review

[source]
Gene namePHLPP1
Protein namePH domain and leucine rich repeat protein phosphatase 1
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
SynonymsPLEKHE1
SCOP
KIAA0606
PHLPP
DescriptionFUNCTION: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA . Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation . Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis . Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation . Inhibits cancer cell proliferation and may act as a tumor suppressor . Dephosphorylates RAF1 inhibiting its kinase activity . May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). .

AccessionsO60346
K7EP91
ENST00000262719.10 [O60346-1]
ENST00000591386.1