TAF6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TAF6 at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0045786Biological processnegative regulation of cell cycle
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0006282Biological processregulation of DNA repair
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0006915Biological processapoptotic process
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0006352Biological processDNA-templated transcription initiation
GO_0071339Cellular componentMLL1 complex
GO_0032991Cellular componentprotein-containing complex
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0005654Cellular componentnucleoplasm
GO_0033276Cellular componenttranscription factor TFTC complex
GO_0046695Cellular componentSLIK (SAGA-like) complex
GO_0005829Cellular componentcytosol
GO_0000124Cellular componentSAGA complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0017162Molecular functionaryl hydrocarbon receptor binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTAF6
Protein nameTranscription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80)
TATA-box binding protein associated factor 6
Transcription initiation factor TFIID subunit 6
Alternative protein TAF6
SynonymsTAFII70
tcag7.663
TAF2E
DescriptionFUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription . TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) . The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 . The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C . TAF6 homodimer connects TFIID modules, forming a rigid core . .; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription . Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis . Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 . In contrast, down-regulates transcription of MDM2 . Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 . Can also activate transcription and apoptosis independently of TP53 . Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA . .

AccessionsC9J088
A0A8I5KSI7
ENST00000417349.5
C9JIS2
ENST00000687672.1 [P49848-4]
ENST00000687410.1 [P49848-1]
ENST00000686580.1 [P49848-1]
ENST00000452438.7
ENST00000685713.1
ENST00000431404.2
ENST00000692408.1 [P49848-4]
ENST00000687447.1 [P49848-1]
ENST00000686096.1
ENST00000690367.1 [P49848-4]
A0A8I5KRU1
ENST00000686172.1 [P49848-4]
ENST00000687216.1
ENST00000688640.1 [P49848-1]
A0A8I5KR77
A4D299
ENST00000687969.1 [P49848-1]
ENST00000691370.1 [P49848-1]
ENST00000689284.1
C9JTY6
L8ECM7
ENST00000692927.1 [P49848-1]
C9JHQ8
A0A8I5KTW4
ENST00000689866.1
ENST00000690206.1
ENST00000437822.6 [P49848-3]
F8WEJ7
ENST00000685280.1 [P49848-1]
ENST00000691534.1
ENST00000693225.1
ENST00000692466.1 [P49848-1]
ENST00000451699.6
ENST00000421980.5
ENST00000684938.1
C9JFL8
ENST00000686777.1 [P49848-1]
ENST00000688343.1 [P49848-1]
ENST00000692029.1
ENST00000493322.6
C9JI39
ENST00000449571.5
ENST00000687151.1 [P49848-4]
ENST00000472509.6 [P49848-1]
ENST00000344095.8 [P49848-1]
ENST00000688498.1 [P49848-1]
ENST00000688086.1
ENST00000690962.1
ENST00000687137.1 [P49848-1]
J3KR72
P49848
ENST00000686141.1
ENST00000472509
ENST00000460673.3 [P49848-1]
ENST00000689684.1
ENST00000691681.1 [P49848-1]
A0A1D5RMS5
ENST00000523306.6
ENST00000460673
ENST00000453269.7 [P49848-1]
ENST00000689754.1 [P49848-1]
A0A8I5KQQ6
ENST00000688091.1
ENST00000691413.1
ENST00000690602.1
ENST00000691010.1 [P49848-4]
ENST00000440225.6
ENST00000452041.5 [P49848-1]