MRPL41 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	29 studies	26% ± 9%	Explore
CD8-positive, alpha-beta T cell	28 studies	31% ± 15%	Explore
CD4-positive, alpha-beta T cell	26 studies	29% ± 14%	Explore
endothelial cell	23 studies	29% ± 11%	Explore
T cell	22 studies	26% ± 7%	Explore
macrophage	22 studies	31% ± 11%	Explore
B cell	21 studies	23% ± 7%	Explore
fibroblast	21 studies	26% ± 11%	Explore
regulatory T cell	20 studies	31% ± 11%	Explore
non-classical monocyte	19 studies	30% ± 13%	Explore
classical monocyte	19 studies	29% ± 12%	Explore
smooth muscle cell	18 studies	24% ± 7%	Explore
conventional dendritic cell	18 studies	31% ± 13%	Explore
pericyte	18 studies	24% ± 6%	Explore
epithelial cell	16 studies	38% ± 20%	Explore
monocyte	16 studies	29% ± 10%	Explore
endothelial cell of lymphatic vessel	15 studies	31% ± 10%	Explore
basal cell	15 studies	31% ± 15%	Explore
ciliated cell	15 studies	55% ± 16%	Explore
gamma-delta T cell	15 studies	28% ± 12%	Explore
mast cell	14 studies	24% ± 7%	Explore
plasmacytoid dendritic cell	14 studies	27% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	28% ± 8%	Explore
memory B cell	13 studies	21% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	22% ± 4%	Explore
mature NK T cell	12 studies	27% ± 5%	Explore
connective tissue cell	11 studies	25% ± 6%	Explore
plasma cell	10 studies	39% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	30% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	33% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	28% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	25% ± 6%	Explore
capillary endothelial cell	10 studies	20% ± 4%	Explore
dendritic cell	10 studies	38% ± 23%	Explore
mucosal invariant T cell	10 studies	24% ± 4%	Explore
plasmablast	9 studies	44% ± 24%	Explore
secretory cell	9 studies	30% ± 16%	Explore
myofibroblast cell	9 studies	22% ± 4%	Explore
goblet cell	9 studies	32% ± 14%	Explore
vein endothelial cell	9 studies	19% ± 3%	Explore
myeloid cell	9 studies	33% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	27% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	35% ± 18%	Explore
progenitor cell	7 studies	39% ± 20%	Explore
astrocyte	7 studies	26% ± 10%	Explore
endothelial cell of artery	7 studies	25% ± 7%	Explore
abnormal cell	7 studies	29% ± 10%	Explore
T follicular helper cell	7 studies	25% ± 4%	Explore
endothelial cell of vascular tree	7 studies	23% ± 3%	Explore
alveolar macrophage	6 studies	26% ± 8%	Explore
type I pneumocyte	6 studies	28% ± 10%	Explore
club cell	6 studies	35% ± 3%	Explore
respiratory goblet cell	6 studies	34% ± 16%	Explore
epithelial cell of proximal tubule	6 studies	40% ± 11%	Explore
renal alpha-intercalated cell	6 studies	47% ± 15%	Explore
enterocyte	6 studies	37% ± 15%	Explore
transit amplifying cell	6 studies	30% ± 12%	Explore
hematopoietic precursor cell	5 studies	33% ± 13%	Explore
exhausted T cell	5 studies	45% ± 13%	Explore
leukocyte	5 studies	27% ± 9%	Explore
naive B cell	5 studies	20% ± 5%	Explore
kidney loop of Henle epithelial cell	5 studies	51% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	39% ± 18%	Explore
neuron	5 studies	39% ± 15%	Explore
enteroendocrine cell	5 studies	38% ± 16%	Explore
type II pneumocyte	5 studies	31% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	36% ± 14%	Explore
ionocyte	4 studies	43% ± 12%	Explore
GABAergic neuron	4 studies	35% ± 19%	Explore
glutamatergic neuron	4 studies	46% ± 21%	Explore
retinal ganglion cell	4 studies	71% ± 24%	Explore
retinal cone cell	4 studies	52% ± 24%	Explore
erythroblast	4 studies	34% ± 14%	Explore
brush cell	4 studies	26% ± 10%	Explore
precursor B cell	4 studies	27% ± 9%	Explore
amacrine cell	4 studies	35% ± 15%	Explore
adventitial cell	4 studies	18% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	38% ± 12%	Explore
innate lymphoid cell	4 studies	21% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	33% ± 7%	Explore
T-helper 17 cell	4 studies	36% ± 21%	Explore
mononuclear phagocyte	4 studies	29% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	21% ± 4%	Explore
deuterosomal cell	3 studies	38% ± 8%	Explore
duct epithelial cell	3 studies	35% ± 14%	Explore
pancreatic A cell	3 studies	49% ± 16%	Explore
type B pancreatic cell	3 studies	44% ± 17%	Explore
intestinal crypt stem cell	3 studies	30% ± 11%	Explore
IgG plasma cell	3 studies	21% ± 6%	Explore
lymphocyte	3 studies	37% ± 12%	Explore
megakaryocyte	3 studies	27% ± 4%	Explore
immature B cell	3 studies	21% ± 4%	Explore
retina horizontal cell	3 studies	34% ± 14%	Explore
retinal rod cell	3 studies	26% ± 4%	Explore
microglial cell	3 studies	25% ± 10%	Explore
serous secreting cell	3 studies	46% ± 11%	Explore
intraepithelial lymphocyte	3 studies	32% ± 8%	Explore
germinal center B cell	3 studies	25% ± 2%	Explore
intermediate monocyte	3 studies	47% ± 12%	Explore
CD4-positive helper T cell	3 studies	24% ± 7%	Explore
hepatocyte	3 studies	60% ± 33%	Explore
luminal cell of prostate epithelium	3 studies	33% ± 9%	Explore
oligodendrocyte precursor cell	3 studies	22% ± 5%	Explore
granulocyte monocyte progenitor cell	3 studies	38% ± 17%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	42% ± 19%	Explore
erythrocyte	3 studies	36% ± 16%	Explore
group 3 innate lymphoid cell	3 studies	28% ± 15%	Explore
keratinocyte	3 studies	22% ± 4%	Explore
T-helper 1 cell	3 studies	37% ± 15%	Explore
double negative thymocyte	3 studies	32% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	33% ± 13%	Explore
peripheral blood	15 studies	28% ± 9%	Explore
intestine	9 studies	28% ± 14%	Explore
kidney	8 studies	30% ± 9%	Explore
brain	7 studies	29% ± 15%	Explore
eye	5 studies	29% ± 11%	Explore
lymph node	4 studies	27% ± 11%	Explore
breast	4 studies	23% ± 7%	Explore
liver	4 studies	36% ± 16%	Explore
pancreas	3 studies	42% ± 20%	Explore
bone marrow	3 studies	26% ± 6%	Explore
uterus	3 studies	40% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	3754.53	258 / 258	100%	354.89	230 / 230
liver	100%	4363.25	226 / 226	100%	327.23	406 / 406
esophagus	100%	2525.36	1441 / 1445	100%	158.81	183 / 183
intestine	100%	3226.05	966 / 966	99%	276.44	522 / 527
brain	100%	6656.93	2639 / 2642	99%	179.50	699 / 705
uterus	99%	2499.59	169 / 170	100%	207.47	457 / 459
stomach	100%	3183.62	359 / 359	99%	228.54	283 / 286
ovary	99%	3111.17	178 / 180	100%	211.45	430 / 430
prostate	100%	6320.73	244 / 245	99%	516.12	498 / 502
thymus	98%	2596.83	642 / 653	100%	200.59	605 / 605
skin	100%	2761.87	1801 / 1809	99%	220.24	466 / 472
bladder	100%	3241.86	21 / 21	98%	239.92	493 / 504
kidney	100%	3735.51	89 / 89	97%	190.42	876 / 901
breast	100%	3174.48	457 / 459	97%	194.60	1089 / 1118
lung	97%	2330.51	558 / 578	97%	149.02	1126 / 1155
pancreas	87%	1244.51	285 / 328	98%	189.44	175 / 178
eye	0%	0	0 / 0	100%	319.39	80 / 80
lymph node	0%	0	0 / 0	100%	322.40	29 / 29
spleen	100%	2887.27	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	177.20	45 / 45
ureter	0%	0	0 / 0	100%	235.54	1 / 1
heart	100%	8779.04	858 / 861	0%	0	0 / 0
muscle	100%	5724.15	800 / 803	0%	0	0 / 0
adipose	100%	3402.34	1198 / 1204	0%	0	0 / 0
blood vessel	98%	2251.14	1307 / 1335	0%	0	0 / 0
peripheral blood	60%	959.15	558 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	MRPL41
Protein name	Large ribosomal subunit protein mL41 (39S ribosomal protein L41, mitochondrial) (L41mt) (MRP-L41) (Bcl-2-interacting mitochondrial ribosomal protein L41) (Cell proliferation-inducing gene 3 protein) (MRP-L27 homolog)
Synonyms	BMRP MRPL27 RPML27 PIG3
Description	FUNCTION: Component of the mitochondrial ribosome large subunit . Also involved in apoptosis and cell cycle . Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins . .
Accessions	Q8IXM3 ENST00000371443.6

GO_0006412	Biological process	translation
GO_0006915	Biological process	apoptotic process
GO_0032543	Biological process	mitochondrial translation
GO_0005762	Cellular component	mitochondrial large ribosomal subunit
GO_0005739	Cellular component	mitochondrion
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0003735	Molecular function	structural constituent of ribosome
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

MRPL41 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review