Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 37 studies | 47% ± 23% | |
endothelial cell of artery | 15 studies | 50% ± 23% | |
fibroblast | 12 studies | 43% ± 19% | |
ciliated cell | 10 studies | 41% ± 19% | |
type I pneumocyte | 9 studies | 60% ± 30% | |
type II pneumocyte | 9 studies | 61% ± 32% | |
basal cell | 9 studies | 42% ± 28% | |
epithelial cell | 8 studies | 39% ± 18% | |
club cell | 8 studies | 58% ± 27% | |
capillary endothelial cell | 8 studies | 32% ± 19% | |
vein endothelial cell | 8 studies | 47% ± 27% | |
smooth muscle cell | 7 studies | 25% ± 9% | |
respiratory goblet cell | 6 studies | 49% ± 27% | |
kidney loop of Henle epithelial cell | 6 studies | 50% ± 34% | |
kidney distal convoluted tubule epithelial cell | 6 studies | 57% ± 31% | |
adipocyte | 6 studies | 48% ± 18% | |
secretory cell | 4 studies | 26% ± 6% | |
myofibroblast cell | 4 studies | 32% ± 14% | |
renal alpha-intercalated cell | 4 studies | 66% ± 31% | |
endothelial cell of vascular tree | 4 studies | 62% ± 25% | |
renal principal cell | 4 studies | 76% ± 23% | |
pericyte | 3 studies | 29% ± 12% | |
endocardial cell | 3 studies | 62% ± 22% | |
glutamatergic neuron | 3 studies | 28% ± 8% | |
intestinal crypt stem cell | 3 studies | 26% ± 7% | |
chondrocyte | 3 studies | 48% ± 13% | |
mucus secreting cell | 3 studies | 49% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
stomach | 100% | 8326.13 | 359 / 359 | 96% | 35.64 | 274 / 286 |
pancreas | 100% | 2857.54 | 328 / 328 | 92% | 21.29 | 163 / 178 |
intestine | 93% | 1980.14 | 899 / 966 | 97% | 28.80 | 512 / 527 |
lung | 100% | 3186.99 | 578 / 578 | 90% | 24.44 | 1042 / 1155 |
bladder | 100% | 3593.33 | 21 / 21 | 89% | 28.24 | 448 / 504 |
esophagus | 100% | 2020.58 | 1440 / 1445 | 80% | 28.57 | 147 / 183 |
uterus | 100% | 1601.49 | 170 / 170 | 77% | 26.82 | 354 / 459 |
kidney | 100% | 4967.09 | 89 / 89 | 64% | 13.36 | 579 / 901 |
ovary | 50% | 381.14 | 90 / 180 | 97% | 43.01 | 419 / 430 |
thymus | 98% | 1324.88 | 642 / 653 | 45% | 4.96 | 271 / 605 |
breast | 100% | 2746.22 | 459 / 459 | 38% | 3.34 | 424 / 1118 |
prostate | 99% | 1648.18 | 243 / 245 | 36% | 2.98 | 180 / 502 |
adipose | 100% | 3273.19 | 1204 / 1204 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 25.82 | 1 / 1 |
heart | 99% | 1498.04 | 856 / 861 | 0% | 0 | 0 / 0 |
spleen | 99% | 913.83 | 239 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 90% | 1544.33 | 1205 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 76% | 17.50 | 34 / 45 |
brain | 58% | 414.03 | 1534 / 2642 | 16% | 1.29 | 110 / 705 |
muscle | 65% | 415.08 | 525 / 803 | 0% | 0 | 0 / 0 |
skin | 44% | 314.21 | 804 / 1809 | 5% | 0.53 | 25 / 472 |
liver | 5% | 24.09 | 11 / 226 | 13% | 1.53 | 52 / 406 |
adrenal gland | 2% | 11.81 | 6 / 258 | 8% | 0.65 | 18 / 230 |
peripheral blood | 0% | 1.57 | 2 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0032259 | Biological process | methylation |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0043069 | Biological process | negative regulation of programmed cell death |
GO_0006338 | Biological process | chromatin remodeling |
GO_0071425 | Biological process | hematopoietic stem cell proliferation |
GO_0070828 | Biological process | heterochromatin organization |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0046329 | Biological process | negative regulation of JNK cascade |
GO_0006915 | Biological process | apoptotic process |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0051726 | Biological process | regulation of cell cycle |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0016607 | Cellular component | nuclear speck |
GO_0005654 | Cellular component | nucleoplasm |
GO_0000118 | Cellular component | histone deacetylase complex |
GO_0005829 | Cellular component | cytosol |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
GO_0046974 | Molecular function | histone H3K9 methyltransferase activity |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0140947 | Molecular function | histone H3K9me2 methyltransferase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0140938 | Molecular function | histone H3 methyltransferase activity |
GO_0140948 | Molecular function | histone H3K9 monomethyltransferase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | MECOM |
Protein name | Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1) MDS1 and EVI1 complex locus |
Synonyms | MDS1 EVI1 PRDM3 |
Description | FUNCTION: [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. .; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. . |
Accessions | ENST00000494597.5 ENST00000492586.1 ENST00000460814.5 ENST00000484519.5 ENST00000472280.5 E9PGE9 ENST00000264674.7 [Q03112-4] ENST00000494292.6 [Q03112-7] ENST00000460890.5 C9JU02 ENST00000628990.2 [Q03112-1] ENST00000475754.5 E7EU48 ENST00000468789.5 [Q03112-1] ENST00000433243.6 E7EPY2 H9KVD4 ENST00000651503.2 [Q03112-3] ENST00000487503.5 Q03112 A0A1B0GXI8 ENST00000466623.1 ENST00000481315.1 ENST00000486748.2 A0A0C3SFZ7 E7EUL6 E7ERX0 ENST00000464456.5 [Q03112-5] |