MECOM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032259Biological processmethylation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0043069Biological processnegative regulation of programmed cell death
GO_0006338Biological processchromatin remodeling
GO_0071425Biological processhematopoietic stem cell proliferation
GO_0070828Biological processheterochromatin organization
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0046329Biological processnegative regulation of JNK cascade
GO_0006915Biological processapoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0000118Cellular componenthistone deacetylase complex
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0046974Molecular functionhistone H3K9 methyltransferase activity
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0140947Molecular functionhistone H3K9me2 methyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0140938Molecular functionhistone H3 methyltransferase activity
GO_0140948Molecular functionhistone H3K9 monomethyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMECOM
Protein nameHistone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)
MDS1 and EVI1 complex locus
SynonymsMDS1
EVI1
PRDM3
DescriptionFUNCTION: [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. .; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. .

AccessionsENST00000494597.5
ENST00000492586.1
ENST00000460814.5
ENST00000484519.5
ENST00000472280.5
E9PGE9
ENST00000264674.7 [Q03112-4]
ENST00000494292.6 [Q03112-7]
ENST00000460890.5
C9JU02
ENST00000628990.2 [Q03112-1]
ENST00000475754.5
E7EU48
ENST00000468789.5 [Q03112-1]
ENST00000433243.6
E7EPY2
H9KVD4
ENST00000651503.2 [Q03112-3]
ENST00000487503.5
Q03112
A0A1B0GXI8
ENST00000466623.1
ENST00000481315.1
ENST00000486748.2
A0A0C3SFZ7
E7EUL6
E7ERX0
ENST00000464456.5 [Q03112-5]