CSNK2A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_1905337Biological processpositive regulation of aggrephagy
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0061077Biological processchaperone-mediated protein folding
GO_0030307Biological processpositive regulation of cell growth
GO_0006302Biological processdouble-strand break repair
GO_0075342Biological processsymbiont-mediated disruption of host cell PML body
GO_0007165Biological processsignal transduction
GO_0006974Biological processDNA damage response
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0050821Biological processprotein stabilization
GO_2001234Biological processnegative regulation of apoptotic signaling pathway
GO_0006915Biological processapoptotic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0016055Biological processWnt signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0048511Biological processrhythmic process
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0051726Biological processregulation of cell cycle
GO_0017148Biological processnegative regulation of translation
GO_1905818Biological processregulation of chromosome separation
GO_0031519Cellular componentPcG protein complex
GO_0005956Cellular componentprotein kinase CK2 complex
GO_0005886Cellular componentplasma membrane
GO_0070822Cellular componentSin3-type complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0051879Molecular functionHsp90 protein binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCSNK2A1
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
Casein kinase 2 alpha 1
SynonymsCK2A1
DescriptionFUNCTION: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine . Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection . May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response . During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage . Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation . Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites . Can also negatively regulate apoptosis . Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 . Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 . Phosphorylates YY1, protecting YY1 from cleavage by CASP7 during apoptosis . Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV . Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB . Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function . Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 . Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 . Acts as an ectokinase that phosphorylates several extracellular proteins . During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV . Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation . Plays an important role in the circadian clock function by phosphorylating BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue . Phosphorylates FMR1, promoting FMR1-dependent formation of a membraneless compartment . .

AccessionsA0A2R8YDY7
ENST00000642160.1
ENST00000609525.2
ENST00000644177.1
ENST00000644003.1 [P68400-2]
A0A087WY74
A0A2R8YCK2
B5BUH5
ENST00000349736.10 [P68400-2]
V9GY80
ENST00000646561.1 [P68400-1]
A0A2R8Y3W6
ENST00000646814.1 [P68400-1]
ENST00000645260.1
ENST00000645091.1
ENST00000645249.1
A0A2R8YCC9
A0A2R8YF43
ENST00000608066.6
ENST00000642689.1
Q5U5J2
ENST00000645840.1
P68400
A0A2R8YD58
A0A2R8YFU2
ENST00000645910.1
A0A2R8YEW1
ENST00000643600.1
ENST00000646908.1
A0A2R8Y7T1
ENST00000645623.1 [P68400-1]
V9GYW6
A0A2R8Y797
V9GYA2
E7EU96
A0A2R8Y4D6
A0A2R8YEL7
ENST00000644885.1
ENST00000643680.1
ENST00000217244.9 [P68400-1]
ENST00000619801.5
ENST00000645234.1
A0A2R8YDP2
ENST00000643910.1
ENST00000645187.1
ENST00000643660.1 [P68400-1]
A0A2R8Y5A0
ENST00000400217.7 [P68400-1]
ENST00000643968.1
A0A2R8Y4H0
ENST00000400227.8
ENST00000644710.1
ENST00000460062.7
ENST00000647026.1
ENST00000646477.1 [P68400-2]
A0A2R8YF47
ENST00000646305.1 [P68400-1]
ENST00000647348.1 [P68400-1]