BCAP31 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904154Biological processpositive regulation of retrograde protein transport, ER to cytosol
GO_0007283Biological processspermatogenesis
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_2001244Biological processpositive regulation of intrinsic apoptotic signaling pathway
GO_0006886Biological processintracellular protein transport
GO_0070973Biological processprotein localization to endoplasmic reticulum exit site
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0006915Biological processapoptotic process
GO_1904294Biological processpositive regulation of ERAD pathway
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0006626Biological processprotein targeting to mitochondrion
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0097038Cellular componentperinuclear endoplasmic reticulum
GO_0030136Cellular componentclathrin-coated vesicle
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0000139Cellular componentGolgi membrane
GO_0044233Cellular componentmitochondria-associated endoplasmic reticulum membrane contact site
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0098553Cellular componentlumenal side of endoplasmic reticulum membrane
GO_0032580Cellular componentGolgi cisterna membrane
GO_0044877Molecular functionprotein-containing complex binding
GO_0042288Molecular functionMHC class I protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBCAP31
Protein nameB-cell receptor-associated protein (BCR-associated protein)
B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) (6C6-AG tumor-associated antigen) (Protein CDM) (p28)
SynonymsDXS1357E
BAP31
DescriptionFUNCTION: Functions as a chaperone protein . Is one of the most abundant endoplasmic reticulum (ER) proteins . Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) . Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 . In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 . May be involved in CASP8-mediated apoptosis . .

FUNCTION: Plays a role in the export of secreted proteins in the ER. .

FUNCTION: Plays a role in the export of secreted proteins in the ER. .

FUNCTION: Plays a role in the export of secreted proteins in the ER. .

FUNCTION: Plays a role in the export of secreted proteins in the ER. .

FUNCTION: Plays a role in the export of secreted proteins in the ER. .

FUNCTION: Plays a role in the export of secreted proteins in the ER. .

AccessionsA0A2R8Y5M6
ENST00000458587.8 [P51572-2]
ENST00000345046.12 [P51572-1]
C9JM14
C9JSP1
ENST00000416815.5
ENST00000645377.1
ENST00000672675.1 [P51572-1]
ENST00000442093.5
ENST00000430088.1
C9JQ75
C9JMD7
ENST00000429550.5
ENST00000423827.5
P51572
C9J0M4
ENST00000647529.1 [P51572-1]