BCL2L10 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of BCL2L10 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BCL2L10 at tissue level.

III. Associated gene sets

GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0007283Biological processspermatogenesis
GO_0043066Biological processnegative regulation of apoptotic process
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0001836Biological processrelease of cytochrome c from mitochondria
GO_0006915Biological processapoptotic process
GO_0031023Biological processmicrotubule organizing center organization
GO_0007292Biological processfemale gamete generation
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0044233Cellular componentmitochondria-associated endoplasmic reticulum membrane contact site
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005741Cellular componentmitochondrial outer membrane
GO_0031965Cellular componentnuclear membrane
GO_0005819Cellular componentspindle
GO_0089720Molecular functioncaspase binding
GO_0005509Molecular functioncalcium ion binding
GO_0051400Molecular functionBH domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBCL2L10
Protein nameBcl-2-like protein 10 (Bcl2-L-10) (Anti-apoptotic protein Boo) (Anti-apoptotic protein NrH) (Apoptosis regulator Bcl-B)
BCL2 like 10
SynonymsDIVA
BCLB
BOO
BCL-B
DescriptionFUNCTION: Promotes cell survival by suppressing apoptosis induced by BAX but not BAK . Increases binding of AHCYL1/IRBIT to ITPR1 . Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions . Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis . Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (By similarity). .

AccessionsENST00000561198.1
ENST00000260442.3
Q9HD36
H0YMD5