APLP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006897Biological processendocytosis
GO_0030900Biological processforebrain development
GO_0009887Biological processanimal organ morphogenesis
GO_0030198Biological processextracellular matrix organization
GO_0007155Biological processcell adhesion
GO_0180011Biological processcytosolic mRNA polyadenylation
GO_0006417Biological processregulation of translation
GO_0007409Biological processaxonogenesis
GO_0071874Biological processcellular response to norepinephrine stimulus
GO_0007417Biological processcentral nervous system development
GO_0006915Biological processapoptotic process
GO_0106072Biological processnegative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0007399Biological processnervous system development
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005604Cellular componentbasement membrane
GO_0008201Molecular functionheparin binding
GO_0031696Molecular functionalpha-2C adrenergic receptor binding
GO_0046914Molecular functiontransition metal ion binding
GO_0042802Molecular functionidentical protein binding
GO_0031694Molecular functionalpha-2A adrenergic receptor binding
GO_0031695Molecular functionalpha-2B adrenergic receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAPLP1
Protein nameAmyloid beta precursor like protein 1
Amyloid beta precursor like protein 1 (cDNA FLJ56046, highly similar to Amyloid-like protein 1 (APLP)(APLP-1))
Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30]
Synonyms
DescriptionFUNCTION: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. .; FUNCTION: The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. .

AccessionsENST00000221891.9 [P51693-2]
ENST00000592316.1
ENST00000587274.1
ENST00000590561.5
P51693
S4R3U6
K7EMN4
ENST00000652533.1 [P51693-1]
F5GZ08
ENST00000589743.5
K7EMS1
B7Z4G8
ENST00000586861.5
K7ELK0
ENST00000588808.5
K7EQJ4
ENST00000537454.6