PTEN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048870Biological processcell motility
GO_0021955Biological processcentral nervous system neuron axonogenesis
GO_2000773Biological processnegative regulation of cellular senescence
GO_0032286Biological processcentral nervous system myelin maintenance
GO_0051895Biological processnegative regulation of focal adhesion assembly
GO_2000463Biological processpositive regulation of excitatory postsynaptic potential
GO_1904668Biological processpositive regulation of ubiquitin protein ligase activity
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0033555Biological processmulticellular organismal response to stress
GO_0050821Biological processprotein stabilization
GO_0090394Biological processnegative regulation of excitatory postsynaptic potential
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0071257Biological processcellular response to electrical stimulus
GO_0007417Biological processcentral nervous system development
GO_0030534Biological processadult behavior
GO_0033137Biological processnegative regulation of peptidyl-serine phosphorylation
GO_0035176Biological processsocial behavior
GO_0045792Biological processnegative regulation of cell size
GO_0007626Biological processlocomotory behavior
GO_0048853Biological processforebrain morphogenesis
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006470Biological processprotein dephosphorylation
GO_0045475Biological processlocomotor rhythm
GO_0046621Biological processnegative regulation of organ growth
GO_0060024Biological processrhythmic synaptic transmission
GO_0010975Biological processregulation of neuron projection development
GO_0030336Biological processnegative regulation of cell migration
GO_0045736Biological processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0097105Biological processpresynaptic membrane assembly
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0097107Biological processpostsynaptic density assembly
GO_0051896Biological processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0021542Biological processdentate gyrus development
GO_0046856Biological processphosphatidylinositol dephosphorylation
GO_0051548Biological processnegative regulation of keratinocyte migration
GO_0010977Biological processnegative regulation of neuron projection development
GO_0007056Biological processspindle assembly involved in female meiosis
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0007416Biological processsynapse assembly
GO_0016477Biological processcell migration
GO_1903690Biological processnegative regulation of wound healing, spreading of epidermal cells
GO_1902807Biological processnegative regulation of cell cycle G1/S phase transition
GO_1904706Biological processnegative regulation of vascular associated smooth muscle cell proliferation
GO_0007507Biological processheart development
GO_0007611Biological processlearning or memory
GO_0050771Biological processnegative regulation of axonogenesis
GO_0007270Biological processneuron-neuron synaptic transmission
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0042711Biological processmaternal behavior
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0060074Biological processsynapse maturation
GO_0006915Biological processapoptotic process
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_2000808Biological processnegative regulation of synaptic vesicle clustering
GO_0060134Biological processprepulse inhibition
GO_0031647Biological processregulation of protein stability
GO_0060997Biological processdendritic spine morphogenesis
GO_0043005Cellular componentneuron projection
GO_0016605Cellular componentPML body
GO_0035749Cellular componentmyelin sheath adaxonal region
GO_0005634Cellular componentnucleus
GO_0005576Cellular componentextracellular region
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0016324Cellular componentapical plasma membrane
GO_0043197Cellular componentdendritic spine
GO_0043220Cellular componentSchmidt-Lanterman incisure
GO_0005829Cellular componentcytosol
GO_0042995Cellular componentcell projection
GO_0051717Molecular functioninositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO_0052866Molecular functionphosphatidylinositol phosphate phosphatase activity
GO_0042802Molecular functionidentical protein binding
GO_0016314Molecular functionphosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO_0051800Molecular functionphosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO_1990381Molecular functionubiquitin-specific protease binding
GO_0004438Molecular functionphosphatidylinositol-3-phosphate phosphatase activity
GO_0004721Molecular functionphosphoprotein phosphatase activity
GO_0017018Molecular functionmyosin phosphatase activity
GO_1990757Molecular functionubiquitin ligase activator activity
GO_0019899Molecular functionenzyme binding
GO_0030351Molecular functioninositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
GO_0008289Molecular functionlipid binding
GO_0030165Molecular functionPDZ domain binding
GO_0005515Molecular functionprotein binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity
GO_0010997Molecular functionanaphase-promoting complex binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene namePTEN
Protein nameMitochondrial PTENalpha
Phosphatase and tensin-like protein
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
Phosphatase and tensin-like protein mutant variant 3
PTENbeta (EC 3.1.3.67)
Phosphatase and tensin homolog
Phosphatase and tensin-like protein (Phosphatase and tensin-like protein mutant variant 2) (Phosphatase and tensin-like protein mutant variant 4) (Phosphatase and tensin-like protein mutant variant 5)
protein-serine/threonine phosphatase (EC 3.1.3.16)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Phosphatase and tensin homolog)
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (EC 3.1.3.67)
SynonymshCG_1737352
MMAC1
TEP1
DescriptionFUNCTION: Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3. .

FUNCTION: Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3. .

FUNCTION: Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3. .

FUNCTION: Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins . Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 . Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate . Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival . The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation . In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement . Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation . Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation . Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation . Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability . .; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. .

FUNCTION: Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3. .

AccessionsENST00000710265.1
A0A2P0XNP6
A0A386NCS8
A0A087X033
ENST00000710387.1 [P60484-2]
A0AA34QVZ8
A0A2R4SE35
A0A142FGX1
A0A8I5KSF9
ENST00000700021.1
A0A8V8TPK6
A0A386NBZ2
ENST00000700029.2
ENST00000706955.1
H6WA52
ENST00000371953.8 [P60484-1]
A0A024QYR6
A0A8V8TQX2
A0A1V0DNR7
A0A8V8TP77
ENST00000688308.1 [P60484-1]
ENST00000688922.2
H6WA46
A0A9L9PYJ2
F6KD01
ENST00000693560.1
A0A8I5KR36
ENST00000686459.1
P60484
H6WA51
ENST00000644628.2 [P60484-1]
ENST00000710385.1 [P60484-1]
ENST00000700022.1
A0A8I5KVQ8
ENST00000472832.3