RRAGC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043200Biological processresponse to amino acid
GO_1903432Biological processregulation of TORC1 signaling
GO_0009267Biological processcellular response to starvation
GO_0031669Biological processcellular response to nutrient levels
GO_0006351Biological processDNA-templated transcription
GO_0008380Biological processRNA splicing
GO_0061462Biological processprotein localization to lysosome
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0034198Biological processcellular response to amino acid starvation
GO_0071230Biological processcellular response to amino acid stimulus
GO_0010507Biological processnegative regulation of autophagy
GO_0006915Biological processapoptotic process
GO_0008104Biological processprotein localization
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0032006Biological processregulation of TOR signaling
GO_0072657Biological processprotein localization to membrane
GO_0005764Cellular componentlysosome
GO_0005654Cellular componentnucleoplasm
GO_1990131Cellular componentGtr1-Gtr2 GTPase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990877Cellular componentFNIP-folliculin RagC/D GAP
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0019003Molecular functionGDP binding
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0140767Molecular functionenzyme-substrate adaptor activity
GO_0051020Molecular functionGTPase binding
GO_0000287Molecular functionmagnesium ion binding
GO_0005525Molecular functionGTP binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRRAGC
Protein nameRas-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929)
Synonyms
DescriptionFUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade . Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) . In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB . This is a crucial step in the activation of the MTOR signaling cascade by amino acids . Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 . .

AccessionsENST00000373001.4
Q9HB90