EMC4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0071816Biological processtail-anchored membrane protein insertion into ER membrane
GO_0045050Biological processprotein insertion into ER membrane by stop-transfer membrane-anchor sequence
GO_0072546Cellular componentEMC complex
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0032977Molecular functionmembrane insertase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEMC4
Protein nameER membrane protein complex subunit 4 (Cell proliferation-inducing gene 17 protein) (Transmembrane protein 85)
ER membrane protein complex subunit 4
ER membrane protein complex subunit 4 (Transmembrane protein 85)
SynonymsPIG17
HSPC184
TMEM85
DescriptionFUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins . Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues . Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices . It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes . By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors . By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). .

AccessionsENST00000559078.5
H0YMH5
Q5J8M3
H0YKL2
ENST00000559421.1
ENST00000560911.5
ENST00000558102.1
H0YNK0
ENST00000249209.8 [Q5J8M3-2]
ENST00000267750.9 [Q5J8M3-1]
ENST00000558205.5
H0YNK8
S4R329
H0YLP8
ENST00000561372.1
H0YN63
H0YK61
ENST00000557879.1
ENST00000560947.1