KANK2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KANK2 at tissue level.

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0030837Biological processnegative regulation of actin filament polymerization
GO_0070563Biological processnegative regulation of vitamin D receptor signaling pathway
GO_0072073Biological processkidney epithelium development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0035023Biological processregulation of Rho protein signal transduction
GO_0043069Biological processnegative regulation of programmed cell death
GO_0033147Biological processnegative regulation of intracellular estrogen receptor signaling pathway
GO_0090521Biological processpodocyte cell migration
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKANK2
Protein nameKN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein)
KN motif and ankyrin repeat domains 2
SynonymsKIAA1518
ANKRD25
SIP
MXRA3
DescriptionFUNCTION: Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 . Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria . Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis . Involved in the negative control of vitamin D receptor signaling pathway . Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway . May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney . Through the Rho signaling pathway may also regulate cell proliferation (By similarity). .

AccessionsK7ES05
ENST00000588787.5
K7ERU2
K7EIU4
ENST00000590685.5
ENST00000588724.5
ENST00000586659.6 [Q63ZY3-1]
ENST00000589894.1 [Q63ZY3-3]
ENST00000589359.5 [Q63ZY3-2]
ENST00000592675.1
K7EL48
Q63ZY3