BEX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006915Biological processapoptotic process
GO_0042981Biological processregulation of apoptotic process
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0051726Biological processregulation of cell cycle
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0140678Molecular functionmolecular function inhibitor activity

IV. Literature review

[source]
Gene nameBEX2
Protein nameProtein BEX2 (Brain-expressed X-linked protein 2) (hBex2)
Brain expressed X-linked 2
Synonyms
DescriptionFUNCTION: Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer . Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA . Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A . Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity . In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). .

AccessionsENST00000449185.1
ENST00000372677.8 [Q9BXY8-1]
X6RDN0
Q9BXY8
ENST00000372674.5 [Q9BXY8-1]
ENST00000536889.1 [Q9BXY8-2]