SEPTIN4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
pericyte	21 studies	35% ± 14%	Explore
oligodendrocyte	14 studies	42% ± 17%	Explore
smooth muscle cell	12 studies	31% ± 16%	Explore
astrocyte	10 studies	38% ± 21%	Explore
retinal cone cell	8 studies	61% ± 27%	Explore
retinal rod cell	8 studies	44% ± 22%	Explore
retina horizontal cell	6 studies	89% ± 7%	Explore
retinal ganglion cell	5 studies	45% ± 29%	Explore
neuron	3 studies	28% ± 14%	Explore
retinal bipolar neuron	3 studies	40% ± 13%	Explore
endothelial cell	3 studies	30% ± 7%	Explore
fibroblast	3 studies	20% ± 7%	Explore
GABAergic neuron	3 studies	30% ± 10%	Explore
glutamatergic neuron	3 studies	33% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	8 studies	29% ± 11%	Explore
eye	8 studies	34% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	35078.75	2642 / 2642	100%	45.25	703 / 705
adrenal gland	96%	8865.03	248 / 258	97%	17.44	222 / 230
breast	65%	2199.82	299 / 459	85%	4.51	950 / 1118
liver	39%	1273.10	89 / 226	77%	9.35	312 / 406
lung	70%	2630.92	404 / 578	44%	1.52	506 / 1155
thymus	31%	882.49	203 / 653	70%	3.02	424 / 605
kidney	35%	1304.06	31 / 89	65%	6.56	588 / 901
eye	0%	0	0 / 0	100%	12.03	80 / 80
spleen	86%	4418.92	208 / 241	0%	0	0 / 0
pancreas	0%	7.15	1 / 328	85%	4.27	151 / 178
blood vessel	84%	3424.02	1125 / 1335	0%	0	0 / 0
skin	1%	25.73	17 / 1809	83%	9.22	390 / 472
adipose	73%	2760.68	877 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	59%	1.95	17 / 29
heart	45%	1406.36	387 / 861	0%	0	0 / 0
uterus	11%	272.42	18 / 170	34%	1.97	154 / 459
stomach	3%	76.86	10 / 359	27%	0.81	76 / 286
intestine	7%	200.55	69 / 966	20%	0.70	108 / 527
bladder	0%	0	0 / 21	27%	0.95	136 / 504
ovary	8%	213.75	15 / 180	17%	0.47	75 / 430
esophagus	6%	166.16	85 / 1445	15%	0.42	28 / 183
tonsil	0%	0	0 / 0	20%	0.58	9 / 45
prostate	2%	58.65	5 / 245	13%	0.35	66 / 502
muscle	1%	15.65	5 / 803	0%	0	0 / 0
peripheral blood	0%	3.49	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0048515	Biological process	spermatid differentiation
GO_2001244	Biological process	positive regulation of intrinsic apoptotic signaling pathway
GO_0061640	Biological process	cytoskeleton-dependent cytokinesis
GO_0017157	Biological process	regulation of exocytosis
GO_0001764	Biological process	neuron migration
GO_0061484	Biological process	hematopoietic stem cell homeostasis
GO_0042981	Biological process	regulation of apoptotic process
GO_0030317	Biological process	flagellated sperm motility
GO_0006915	Biological process	apoptotic process
GO_0031398	Biological process	positive regulation of protein ubiquitination
GO_0008104	Biological process	protein localization
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0098793	Cellular component	presynapse
GO_0032153	Cellular component	cell division site
GO_0005739	Cellular component	mitochondrion
GO_0043204	Cellular component	perikaryon
GO_0097227	Cellular component	sperm annulus
GO_0005654	Cellular component	nucleoplasm
GO_0098691	Cellular component	dopaminergic synapse
GO_0030425	Cellular component	dendrite
GO_0005829	Cellular component	cytosol
GO_0008021	Cellular component	synaptic vesicle
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0031105	Cellular component	septin complex
GO_0005940	Cellular component	septin ring
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0030424	Cellular component	axon
GO_0005634	Cellular component	nucleus
GO_0060090	Molecular function	molecular adaptor activity
GO_0042802	Molecular function	identical protein binding
GO_0000287	Molecular function	magnesium ion binding
GO_0005198	Molecular function	structural molecule activity
GO_0005525	Molecular function	GTP binding
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	SEPTIN4
Protein name	Septin-4 (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Peanut-like protein 2) Septin-4 Septin Alternative protein SEPT4 Septin 4, isoform CRA_h (cDNA FLJ33746 fis, clone BRCAN1000105, highly similar to Homo sapiens septin 4 (SEPT4), transcript variant 2, mRNA) Septin 4
Synonyms	C17orf47 hCG_30696 SEP4 SEPT4 PNUTL2 hucep-7
Description	FUNCTION: Filament-forming cytoskeletal GTPase (Probable). Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (By similarity). May also play a role in the regulation of cell fate in the intestine (By similarity). Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis; via its interaction with XIAP (By similarity). Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP (By similarity). Plays an important role in male fertility and sperm motility (By similarity). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (By similarity). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Required for dopaminergic metabolism in presynaptic autoreceptors; potentially via activity as a presynaptic scaffold protein (By similarity). .; FUNCTION: [Isoform ARTS]: Required for the induction of cell death mediated by TGF-beta and possibly by other apoptotic stimuli . Induces apoptosis through binding and inhibition of XIAP resulting in significant reduction in XIAP levels, leading to caspase activation and cell death . Mediates the interaction between BCL2 and XIAP, thereby positively regulating the ubiquitination and degradation of BCL2 and promoting apoptosis . . FUNCTION: Filament-forming cytoskeletal GTPase. .
Accessions	ENST00000580809.5 ENST00000583114.5 [O43236-5] B3KR63 ENST00000412945.7 [O43236-3] J3KSZ7 ENST00000580844.5 ENST00000672673.2 [O43236-7] ENST00000672699.1 [O43236-4] J3QRT6 L8EAN1 ENST00000579371.5 J3QRS4 ENST00000578131.5 ENST00000671766.1 J3KS26 ENST00000581607.1 O43236 ENST00000321691.3 [O43236-8] J3QLR2 J3QRU3 ENST00000317256.10 [O43236-2] ENST00000426861.5 [O43236-6] A0A5F9ZHS9 J3QLA8 ENST00000393086.5 [O43236-2] ENST00000317268.7 [O43236-1] ENST00000581615.5 J3KS85 ENST00000583291.1 ENST00000577729.5 ENST00000457347.6 [O43236-4]

SEPTIN4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review