Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 23 studies | 39% ± 19% | |
astrocyte | 19 studies | 36% ± 19% | |
oligodendrocyte | 15 studies | 57% ± 18% | |
oligodendrocyte precursor cell | 15 studies | 56% ± 22% | |
macrophage | 15 studies | 40% ± 21% | |
microglial cell | 13 studies | 48% ± 10% | |
glutamatergic neuron | 11 studies | 45% ± 25% | |
fibroblast | 10 studies | 30% ± 11% | |
GABAergic neuron | 8 studies | 46% ± 21% | |
pericyte | 8 studies | 31% ± 10% | |
smooth muscle cell | 8 studies | 27% ± 9% | |
myeloid cell | 7 studies | 35% ± 11% | |
adipocyte | 7 studies | 28% ± 7% | |
type I pneumocyte | 7 studies | 33% ± 13% | |
basal cell | 7 studies | 34% ± 19% | |
interneuron | 6 studies | 42% ± 19% | |
epithelial cell | 6 studies | 40% ± 17% | |
ciliated cell | 6 studies | 23% ± 8% | |
T cell | 6 studies | 25% ± 7% | |
endothelial cell of lymphatic vessel | 6 studies | 31% ± 10% | |
type II pneumocyte | 6 studies | 33% ± 10% | |
neuron | 5 studies | 43% ± 22% | |
cardiac muscle cell | 5 studies | 35% ± 8% | |
monocyte | 5 studies | 36% ± 10% | |
club cell | 5 studies | 39% ± 15% | |
regulatory T cell | 5 studies | 30% ± 8% | |
glial cell | 4 studies | 31% ± 9% | |
granule cell | 4 studies | 31% ± 9% | |
retinal pigment epithelial cell | 4 studies | 54% ± 25% | |
B cell | 4 studies | 27% ± 8% | |
dendritic cell | 4 studies | 22% ± 2% | |
mesothelial cell | 4 studies | 29% ± 7% | |
Mueller cell | 4 studies | 37% ± 12% | |
retinal rod cell | 4 studies | 48% ± 17% | |
hepatocyte | 4 studies | 56% ± 20% | |
erythrocyte | 4 studies | 47% ± 24% | |
GABAergic interneuron | 3 studies | 32% ± 4% | |
CD4-positive, alpha-beta T cell | 3 studies | 24% ± 2% | |
mast cell | 3 studies | 28% ± 10% | |
ependymal cell | 3 studies | 45% ± 20% | |
alveolar macrophage | 3 studies | 46% ± 10% | |
capillary endothelial cell | 3 studies | 35% ± 20% | |
natural killer cell | 3 studies | 24% ± 1% | |
respiratory goblet cell | 3 studies | 40% ± 13% | |
lymphocyte | 3 studies | 35% ± 18% | |
mucus secreting cell | 3 studies | 37% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 1739.77 | 245 / 245 | 100% | 35.60 | 501 / 502 |
lung | 100% | 2455.44 | 578 / 578 | 100% | 22.49 | 1150 / 1155 |
esophagus | 100% | 1654.48 | 1445 / 1445 | 99% | 20.73 | 182 / 183 |
brain | 100% | 1505.95 | 2641 / 2642 | 99% | 17.62 | 700 / 705 |
thymus | 100% | 2063.93 | 653 / 653 | 99% | 38.09 | 600 / 605 |
breast | 100% | 1679.85 | 459 / 459 | 99% | 20.02 | 1107 / 1118 |
ovary | 100% | 1682.88 | 180 / 180 | 98% | 16.91 | 423 / 430 |
bladder | 100% | 1962.62 | 21 / 21 | 98% | 14.55 | 492 / 504 |
uterus | 100% | 1637.84 | 170 / 170 | 97% | 15.42 | 445 / 459 |
kidney | 100% | 1718.72 | 89 / 89 | 96% | 17.80 | 869 / 901 |
pancreas | 100% | 881.03 | 327 / 328 | 97% | 12.88 | 172 / 178 |
intestine | 100% | 1535.87 | 965 / 966 | 95% | 11.82 | 503 / 527 |
adrenal gland | 100% | 2542.05 | 258 / 258 | 95% | 12.44 | 219 / 230 |
stomach | 100% | 1334.00 | 359 / 359 | 95% | 14.30 | 271 / 286 |
liver | 100% | 1117.83 | 226 / 226 | 94% | 12.23 | 382 / 406 |
skin | 100% | 2740.88 | 1809 / 1809 | 58% | 4.75 | 274 / 472 |
adipose | 100% | 1954.70 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1852.97 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1054.59 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 15.36 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.31 | 1 / 1 |
muscle | 99% | 973.10 | 798 / 803 | 0% | 0 | 0 / 0 |
heart | 96% | 1145.38 | 829 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 10.00 | 26 / 29 |
peripheral blood | 83% | 1284.52 | 771 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 16% | 0.87 | 13 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006915 | Biological process | apoptotic process |
GO_0030148 | Biological process | sphingolipid biosynthetic process |
GO_2001242 | Biological process | regulation of intrinsic apoptotic signaling pathway |
GO_0006686 | Biological process | sphingomyelin biosynthetic process |
GO_0046513 | Biological process | ceramide biosynthetic process |
GO_0000138 | Cellular component | Golgi trans cisterna |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005634 | Cellular component | nucleus |
GO_0047493 | Molecular function | ceramide cholinephosphotransferase activity |
GO_0002950 | Molecular function | ceramide phosphoethanolamine synthase activity |
GO_0033188 | Molecular function | sphingomyelin synthase activity |
GO_0016301 | Molecular function | kinase activity |
Gene name | SGMS1 |
Protein name | Phosphatidylcholine:ceramide cholinephosphotransferase 1 (EC 2.7.8.27) (Medulla oblongata-derived protein) (Protein Mob) (Sphingomyelin synthase 1) (Transmembrane protein 23) Sphingomyelin synthase 1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 (EC 2.7.8.27) (Sphingomyelin synthase 1) |
Synonyms | SMS1 MOB TMEM23 |
Description | FUNCTION: Major sphingomyelin synthase at the Golgi apparatus . Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes . Does not use free phosphorylcholine or CDP-choline as donor . Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting . Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 . . |
Accessions | ENST00000626236.2 E6ZCI7 ENST00000602565.2 E6ZCI6 U3KQ11 C0MHM2 ENST00000361543.3 R4GNI5 ENST00000361781.7 [Q86VZ5-1] ENST00000429490.5 Q86VZ5 ENST00000619438.4 ENST00000602619.1 |