Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 25 studies | 23% ± 5% | |
memory B cell | 16 studies | 21% ± 4% | |
naive B cell | 12 studies | 21% ± 3% | |
CD16-negative, CD56-bright natural killer cell, human | 9 studies | 19% ± 6% | |
CD8-positive, alpha-beta T cell | 6 studies | 21% ± 6% | |
smooth muscle cell | 6 studies | 22% ± 4% | |
natural killer cell | 4 studies | 20% ± 4% | |
endothelial cell | 4 studies | 21% ± 4% | |
mast cell | 4 studies | 17% ± 2% | |
gamma-delta T cell | 4 studies | 20% ± 2% | |
T cell | 3 studies | 18% ± 2% | |
CD4-positive, alpha-beta T cell | 3 studies | 16% ± 0% | |
exhausted T cell | 3 studies | 25% ± 5% | |
lymphocyte | 3 studies | 32% ± 5% | |
GABAergic neuron | 3 studies | 20% ± 1% | |
glutamatergic neuron | 3 studies | 25% ± 7% | |
macrophage | 3 studies | 17% ± 1% | |
regulatory T cell | 3 studies | 16% ± 0% | |
brush cell | 3 studies | 23% ± 6% | |
abnormal cell | 3 studies | 17% ± 1% |
Insufficient scRNA-seq data for expression of TRAF5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 2808.76 | 459 / 459 | 98% | 18.68 | 1098 / 1118 |
intestine | 100% | 5217.61 | 966 / 966 | 98% | 18.78 | 516 / 527 |
stomach | 100% | 2756.06 | 359 / 359 | 97% | 16.65 | 277 / 286 |
pancreas | 100% | 4565.73 | 328 / 328 | 93% | 11.54 | 166 / 178 |
lung | 99% | 2435.99 | 575 / 578 | 93% | 9.31 | 1077 / 1155 |
uterus | 99% | 6444.35 | 169 / 170 | 88% | 9.50 | 403 / 459 |
bladder | 100% | 4698.10 | 21 / 21 | 86% | 9.97 | 431 / 504 |
esophagus | 95% | 3623.60 | 1377 / 1445 | 90% | 10.08 | 165 / 183 |
ovary | 99% | 2411.95 | 179 / 180 | 86% | 6.64 | 368 / 430 |
skin | 85% | 1148.18 | 1537 / 1809 | 92% | 10.98 | 434 / 472 |
kidney | 98% | 1751.53 | 87 / 89 | 77% | 5.98 | 693 / 901 |
prostate | 100% | 3732.62 | 244 / 245 | 66% | 3.59 | 332 / 502 |
adrenal gland | 94% | 1178.61 | 243 / 258 | 59% | 3.43 | 135 / 230 |
thymus | 88% | 1321.96 | 577 / 653 | 38% | 3.28 | 230 / 605 |
blood vessel | 100% | 6530.88 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 23.38 | 29 / 29 |
spleen | 100% | 6789.38 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.94 | 1 / 1 |
adipose | 100% | 3321.47 | 1203 / 1204 | 0% | 0 | 0 / 0 |
brain | 47% | 508.82 | 1230 / 2642 | 48% | 3.05 | 335 / 705 |
tonsil | 0% | 0 | 0 / 0 | 73% | 4.95 | 33 / 45 |
peripheral blood | 62% | 1711.22 | 579 / 929 | 0% | 0 | 0 / 0 |
heart | 54% | 610.86 | 463 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 54% | 4.50 | 43 / 80 |
liver | 14% | 114.18 | 31 / 226 | 32% | 2.49 | 128 / 406 |
muscle | 11% | 105.47 | 92 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
GO_0007165 | Biological process | signal transduction |
GO_0048255 | Biological process | mRNA stabilization |
GO_0023019 | Biological process | signal transduction involved in regulation of gene expression |
GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0070534 | Biological process | protein K63-linked ubiquitination |
GO_0006915 | Biological process | apoptotic process |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0043122 | Biological process | regulation of canonical NF-kappaB signal transduction |
GO_0033209 | Biological process | tumor necrosis factor-mediated signaling pathway |
GO_0097400 | Biological process | interleukin-17-mediated signaling pathway |
GO_0009898 | Cellular component | cytoplasmic side of plasma membrane |
GO_0005813 | Cellular component | centrosome |
GO_0098802 | Cellular component | plasma membrane signaling receptor complex |
GO_0035631 | Cellular component | CD40 receptor complex |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0031996 | Molecular function | thioesterase binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0005164 | Molecular function | tumor necrosis factor receptor binding |
GO_0005515 | Molecular function | protein binding |
Gene name | TRAF5 |
Protein name | TNF receptor-associated factor 5 (RING finger protein 84) |
Synonyms | RNF84 |
Description | FUNCTION: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. . |
Accessions | ENST00000367004.3 [O00463-1] ENST00000336184.6 [O00463-1] ENST00000261464.10 [O00463-1] O00463 |