TRAF5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRAF5 at tissue level.

III. Associated gene sets

GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0007165Biological processsignal transduction
GO_0048255Biological processmRNA stabilization
GO_0023019Biological processsignal transduction involved in regulation of gene expression
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0042981Biological processregulation of apoptotic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0006915Biological processapoptotic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0097400Biological processinterleukin-17-mediated signaling pathway
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0005813Cellular componentcentrosome
GO_0098802Cellular componentplasma membrane signaling receptor complex
GO_0035631Cellular componentCD40 receptor complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031996Molecular functionthioesterase binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008270Molecular functionzinc ion binding
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRAF5
Protein nameTNF receptor-associated factor 5 (RING finger protein 84)
SynonymsRNF84
DescriptionFUNCTION: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. .

AccessionsENST00000367004.3 [O00463-1]
ENST00000336184.6 [O00463-1]
ENST00000261464.10 [O00463-1]
O00463