DAP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010507Biological processnegative regulation of autophagy
GO_0006915Biological processapoptotic process
GO_0097190Biological processapoptotic signaling pathway
GO_0006914Biological processautophagy
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0034198Biological processcellular response to amino acid starvation
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0006417Biological processregulation of translation
GO_0070513Molecular functiondeath domain binding

IV. Literature review

[source]
Gene nameDAP
Protein nameDeath-associated protein
Death-associated protein 1 (DAP-1)
Death associated protein (cDNA FLJ55133, weakly similar to Death-associated protein 1)
SynonymshCG_37855
DAP1
DescriptionFUNCTION: Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (By similarity). Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy . Involved in mediating interferon-gamma-induced cell death . .

AccessionsB4DQ75
ENST00000230895.11
P51397
ENST00000432074.2
Q7KZT7