STEAP3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of STEAP3 at tissue level.

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0015677Biological processcopper ion import
GO_0033572Biological processtransferrin transport
GO_0009306Biological processprotein secretion
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0005886Cellular componentplasma membrane
GO_0005771Cellular componentmultivesicular body
GO_0005737Cellular componentcytoplasm
GO_0008823Molecular functioncupric reductase (NADH) activity
GO_0052851Molecular functionferric-chelate reductase (NADPH) activity
GO_0071949Molecular functionFAD binding
GO_0016723Molecular functionoxidoreductase activity, acting on metal ions, NAD or NADP as acceptor
GO_0020037Molecular functionheme binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameSTEAP3
Protein nameMetalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde)
STEAP family member 3, isoform CRA_c (STEAP3 metalloreductase)
SynonymshCG_18273
TSAP6
DescriptionFUNCTION: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane . Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). Mediates efficient transferrin-dependent iron uptake in erythroid cells (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP . .

AccessionsENST00000393107.2 [Q658P3-1]
ENST00000393110.7 [Q658P3-2]
ENST00000409811.5
B8ZZX6
ENST00000393106.6 [Q658P3-1]
Q658P3