TAOK2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TAOK2 at tissue level.

III. Associated gene sets

GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0032874Biological processpositive regulation of stress-activated MAPK cascade
GO_0001558Biological processregulation of cell growth
GO_0046330Biological processpositive regulation of JNK cascade
GO_0006974Biological processDNA damage response
GO_0150020Biological processbasal dendrite arborization
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0006612Biological processprotein targeting to membrane
GO_0007409Biological processaxonogenesis
GO_0051403Biological processstress-activated MAPK cascade
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_0032147Biological processactivation of protein kinase activity
GO_0030036Biological processactin cytoskeleton organization
GO_0048041Biological processfocal adhesion assembly
GO_0006915Biological processapoptotic process
GO_0031954Biological processpositive regulation of protein autophosphorylation
GO_0008360Biological processregulation of cell shape
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0150019Biological processbasal dendrite morphogenesis
GO_0016477Biological processcell migration
GO_0005730Cellular componentnucleolus
GO_0043235Cellular componentreceptor complex
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005654Cellular componentnucleoplasm
GO_0043005Cellular componentneuron projection
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0044294Cellular componentdendritic growth cone
GO_0044295Cellular componentaxonal growth cone
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0031434Molecular functionmitogen-activated protein kinase kinase binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0004709Molecular functionMAP kinase kinase kinase activity
GO_0050321Molecular functiontau-protein kinase activity
GO_0005524Molecular functionATP binding
GO_0048156Molecular functiontau protein binding
GO_0005515Molecular functionprotein binding
GO_0038191Molecular functionneuropilin binding

IV. Literature review

[source]
Gene nameTAOK2
Protein nameSerine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
SynonymsPSK
PSK1
MAP3K17
KIAA0881
UNQ2971/PRO7431
DescriptionFUNCTION: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. .

AccessionsENST00000543033.5 [Q9UL54-4]
Q6PIN8
A0PJ48
ENST00000279394.7 [Q9UL54-2]
Q9UL54
ENST00000416441.2 [Q9UL54-3]
ENST00000308893.9 [Q9UL54-1]
Q86V37