MX1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
plasmacytoid dendritic cell	19 studies	38% ± 19%	Explore
endothelial cell	15 studies	30% ± 12%	Explore
B cell	15 studies	25% ± 11%	Explore
macrophage	13 studies	24% ± 7%	Explore
regulatory T cell	13 studies	25% ± 10%	Explore
non-classical monocyte	10 studies	26% ± 8%	Explore
conventional dendritic cell	9 studies	24% ± 7%	Explore
memory B cell	8 studies	25% ± 7%	Explore
monocyte	8 studies	33% ± 16%	Explore
natural killer cell	8 studies	25% ± 6%	Explore
naive B cell	8 studies	26% ± 11%	Explore
classical monocyte	8 studies	27% ± 8%	Explore
endothelial cell of artery	8 studies	24% ± 6%	Explore
plasmablast	7 studies	37% ± 18%	Explore
endothelial cell of vascular tree	7 studies	24% ± 5%	Explore
CD8-positive, alpha-beta T cell	7 studies	25% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	22% ± 4%	Explore
T cell	6 studies	27% ± 12%	Explore
basal cell	6 studies	22% ± 9%	Explore
ciliated cell	6 studies	26% ± 7%	Explore
CD4-positive, alpha-beta T cell	6 studies	22% ± 7%	Explore
dendritic cell	6 studies	34% ± 12%	Explore
alveolar macrophage	5 studies	22% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	22% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	19% ± 2%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	25% ± 8%	Explore
plasma cell	4 studies	32% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
capillary endothelial cell	4 studies	26% ± 7%	Explore
myeloid cell	4 studies	30% ± 7%	Explore
gamma-delta T cell	4 studies	21% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	25% ± 7%	Explore
epithelial cell	3 studies	29% ± 5%	Explore
secretory cell	3 studies	31% ± 8%	Explore
squamous epithelial cell	3 studies	34% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	19% ± 1%	Explore
vein endothelial cell	3 studies	26% ± 9%	Explore
double negative thymocyte	3 studies	22% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	25% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	8 studies	20% ± 5%	Explore
lung	4 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	3611.33	652 / 653	94%	33.45	567 / 605
esophagus	100%	3325.74	1444 / 1445	89%	47.82	162 / 183
ovary	100%	3087.81	180 / 180	86%	64.59	371 / 430
uterus	99%	2341.21	168 / 170	87%	69.85	399 / 459
breast	100%	3018.02	458 / 459	86%	73.89	956 / 1118
lung	100%	3590.41	578 / 578	83%	39.31	963 / 1155
kidney	100%	3718.01	89 / 89	70%	16.23	629 / 901
bladder	95%	1804.57	20 / 21	74%	44.81	375 / 504
stomach	99%	2185.19	356 / 359	69%	26.18	196 / 286
intestine	100%	2563.62	964 / 966	65%	24.96	342 / 527
adrenal gland	98%	1816.78	253 / 258	59%	24.78	136 / 230
pancreas	60%	575.30	198 / 328	88%	44.02	157 / 178
liver	90%	1560.35	204 / 226	49%	17.28	200 / 406
brain	92%	2096.63	2436 / 2642	46%	22.53	324 / 705
prostate	100%	2021.31	245 / 245	35%	10.81	176 / 502
skin	67%	957.16	1207 / 1809	67%	38.84	316 / 472
spleen	100%	8134.85	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	12.61	1 / 1
adipose	100%	3064.75	1200 / 1204	0%	0	0 / 0
blood vessel	98%	2639.09	1308 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	86.75	43 / 45
peripheral blood	92%	11846.07	859 / 929	0%	0	0 / 0
heart	91%	1324.63	781 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	83%	60.98	24 / 29
eye	0%	0	0 / 0	49%	20.22	39 / 80
muscle	37%	326.52	296 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045071	Biological process	negative regulation of viral genome replication
GO_0140374	Biological process	antiviral innate immune response
GO_0045087	Biological process	innate immune response
GO_0007165	Biological process	signal transduction
GO_0009615	Biological process	response to virus
GO_0051607	Biological process	defense response to virus
GO_0006915	Biological process	apoptotic process
GO_0034340	Biological process	response to type I interferon
GO_0070106	Biological process	interleukin-27-mediated signaling pathway
GO_0006952	Biological process	defense response
GO_0005874	Cellular component	microtubule
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0031965	Cellular component	nuclear membrane
GO_0005634	Cellular component	nucleus
GO_0042802	Molecular function	identical protein binding
GO_0005525	Molecular function	GTP binding
GO_0008017	Molecular function	microtubule binding
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	MX1
Protein name	Interferon-induced GTP-binding protein Mx1 Interferon-induced GTP-binding protein Mx1 (Interferon-induced protein p78) (IFI-78K) (Interferon-regulated resistance GTP-binding protein MxA) (Myxoma resistance protein 1) (Myxovirus resistance protein 1) [Cleaved into: Interferon-induced GTP-binding protein Mx1, N-terminally processed] MX dynamin like GTPase 1
Synonyms
Description	FUNCTION: Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs. .
Accessions	ENST00000455164.6 [P20591-1] ENST00000681849.1 [P20591-1] ENST00000680347.1 [P20591-1] P20591 ENST00000681415.1 [P20591-1] H9KVC7 ENST00000679445.1 [P20591-1] ENST00000680629.1 [P20591-1] ENST00000681867.1 [P20591-1] ENST00000679408.1 ENST00000419044 ENST00000679705.1 [P20591-1] ENST00000681671.1 [P20591-1] A0A7P0T9I6 ENST00000288383.11 ENST00000681191.1 [P20591-1] ENST00000681607.1 [P20591-1] ENST00000680776.1 [P20591-1] ENST00000680176.1 [P20591-1] ENST00000680760.1 [P20591-1] ENST00000681857.1 [P20591-1] ENST00000398600.6 [P20591-1] ENST00000680536.1 [P20591-1] ENST00000681896.1 [P20591-1] ENST00000419044.6 [P20591-1] ENST00000681039.1 [P20591-1] H9KVD0 ENST00000619682.1 [P20591-2] ENST00000424365.6 ENST00000679626.1 [P20591-1] ENST00000680182.1 [P20591-1] ENST00000680942.1 F8W8T1 ENST00000413778 ENST00000413778.6 [P20591-1] ENST00000679543.1 [P20591-1] H9KVC3 ENST00000679386.1 ENST00000681266.1 [P20591-1] ENST00000417963 A0A7P0Z4E0 ENST00000680364.1 [P20591-1] A0A7P0T9R0 ENST00000679464.1 [P20591-1] ENST00000679911.1 [P20591-1] H9KVC9 ENST00000681944.1 ENST00000417963.6 [P20591-1] ENST00000398598.8 [P20591-1]

MX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review