Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 7 studies | 24% ± 8% | |
astrocyte | 7 studies | 25% ± 10% | |
kidney loop of Henle epithelial cell | 6 studies | 21% ± 4% | |
enterocyte | 6 studies | 45% ± 11% | |
epithelial cell | 6 studies | 34% ± 14% | |
glutamatergic neuron | 5 studies | 35% ± 15% | |
adipocyte | 4 studies | 19% ± 2% | |
GABAergic neuron | 4 studies | 33% ± 12% | |
oligodendrocyte precursor cell | 4 studies | 25% ± 9% | |
oligodendrocyte | 4 studies | 22% ± 5% | |
goblet cell | 3 studies | 20% ± 5% | |
microglial cell | 3 studies | 21% ± 3% | |
enteroendocrine cell | 3 studies | 20% ± 4% | |
interneuron | 3 studies | 37% ± 19% | |
neuron | 3 studies | 25% ± 9% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 32% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 2911.03 | 245 / 245 | 100% | 7.27 | 502 / 502 |
esophagus | 100% | 1295.62 | 1443 / 1445 | 99% | 5.49 | 182 / 183 |
thymus | 100% | 1997.40 | 653 / 653 | 99% | 3.92 | 599 / 605 |
intestine | 100% | 2416.42 | 965 / 966 | 99% | 5.18 | 522 / 527 |
pancreas | 100% | 2301.59 | 328 / 328 | 99% | 4.19 | 176 / 178 |
uterus | 100% | 1838.67 | 170 / 170 | 98% | 3.97 | 450 / 459 |
stomach | 100% | 2045.11 | 359 / 359 | 98% | 6.54 | 280 / 286 |
breast | 99% | 1266.90 | 453 / 459 | 99% | 5.18 | 1104 / 1118 |
brain | 98% | 1472.20 | 2600 / 2642 | 98% | 4.30 | 690 / 705 |
bladder | 100% | 1473.43 | 21 / 21 | 96% | 3.74 | 483 / 504 |
adrenal gland | 98% | 1180.19 | 254 / 258 | 97% | 3.60 | 223 / 230 |
ovary | 100% | 1686.25 | 180 / 180 | 93% | 3.14 | 398 / 430 |
lung | 98% | 1248.18 | 567 / 578 | 94% | 3.80 | 1088 / 1155 |
skin | 99% | 1071.88 | 1788 / 1809 | 93% | 3.15 | 437 / 472 |
kidney | 100% | 3845.78 | 89 / 89 | 84% | 5.74 | 758 / 901 |
liver | 93% | 615.31 | 211 / 226 | 41% | 1.17 | 165 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 5.50 | 29 / 29 |
spleen | 100% | 2452.69 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 1.31 | 1 / 1 |
blood vessel | 98% | 1025.84 | 1303 / 1335 | 0% | 0 | 0 / 0 |
adipose | 97% | 1125.54 | 1170 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 95% | 1252.23 | 884 / 929 | 0% | 0 | 0 / 0 |
heart | 94% | 757.86 | 811 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 2.91 | 41 / 45 |
eye | 0% | 0 | 0 / 0 | 63% | 1.35 | 50 / 80 |
muscle | 59% | 305.78 | 475 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0070948 | Biological process | regulation of neutrophil mediated cytotoxicity |
GO_0006915 | Biological process | apoptotic process |
GO_0006308 | Biological process | DNA catabolic process |
GO_0002673 | Biological process | regulation of acute inflammatory response |
GO_0002283 | Biological process | neutrophil activation involved in immune response |
GO_0042588 | Cellular component | zymogen granule |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005576 | Cellular component | extracellular region |
GO_0005635 | Cellular component | nuclear envelope |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0003779 | Molecular function | actin binding |
GO_0004530 | Molecular function | deoxyribonuclease I activity |
Gene name | DNASE1 |
Protein name | Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) Alternative protein DNASE1 Deoxyribonuclease 1 (Deoxyribonuclease I) Deoxyribonuclease 1 Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) (Dornase alfa) |
Synonyms | DRNI DNAse1 DNL1 |
Description | FUNCTION: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs . Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis . Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). . |
Accessions | I3L4C7 ENST00000571460.5 ENST00000575479.1 I3L530 ENST00000570807.5 ENST00000246949.10 [P24855-1] ENST00000576050.5 L8ECC1 ENST00000572237.1 I3L298 ENST00000576792.1 ENST00000570769.5 ENST00000570664.1 I3L4B8 ENST00000407479.5 [P24855-1] P24855 I3L0Z9 I3L4U3 ENST00000570376.5 A0A089NFS3 I3L1N2 |