DNASE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070948Biological processregulation of neutrophil mediated cytotoxicity
GO_0006915Biological processapoptotic process
GO_0006308Biological processDNA catabolic process
GO_0002673Biological processregulation of acute inflammatory response
GO_0002283Biological processneutrophil activation involved in immune response
GO_0042588Cellular componentzymogen granule
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0005635Cellular componentnuclear envelope
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0004530Molecular functiondeoxyribonuclease I activity

IV. Literature review

[source]
Gene nameDNASE1
Protein nameDeoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I)
Alternative protein DNASE1
Deoxyribonuclease 1 (Deoxyribonuclease I)
Deoxyribonuclease 1
Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) (Dornase alfa)
SynonymsDRNI
DNAse1
DNL1
DescriptionFUNCTION: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs . Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis . Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). .

AccessionsI3L4C7
ENST00000571460.5
ENST00000575479.1
I3L530
ENST00000570807.5
ENST00000246949.10 [P24855-1]
ENST00000576050.5
L8ECC1
ENST00000572237.1
I3L298
ENST00000576792.1
ENST00000570769.5
ENST00000570664.1
I3L4B8
ENST00000407479.5 [P24855-1]
P24855
I3L0Z9
I3L4U3
ENST00000570376.5
A0A089NFS3
I3L1N2