BAG1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	20 studies	23% ± 6%	Explore
basal cell	19 studies	44% ± 17%	Explore
endothelial cell	18 studies	27% ± 12%	Explore
smooth muscle cell	17 studies	27% ± 10%	Explore
plasmacytoid dendritic cell	17 studies	39% ± 11%	Explore
epithelial cell	17 studies	43% ± 19%	Explore
classical monocyte	17 studies	24% ± 12%	Explore
ciliated cell	16 studies	34% ± 19%	Explore
pericyte	16 studies	25% ± 6%	Explore
conventional dendritic cell	15 studies	27% ± 18%	Explore
non-classical monocyte	15 studies	29% ± 15%	Explore
fibroblast	15 studies	25% ± 9%	Explore
macrophage	14 studies	23% ± 8%	Explore
monocyte	11 studies	24% ± 9%	Explore
secretory cell	10 studies	46% ± 21%	Explore
B cell	10 studies	23% ± 6%	Explore
endothelial cell of lymphatic vessel	9 studies	22% ± 6%	Explore
plasma cell	9 studies	30% ± 11%	Explore
goblet cell	9 studies	37% ± 10%	Explore
endothelial cell of vascular tree	9 studies	22% ± 4%	Explore
gamma-delta T cell	9 studies	24% ± 13%	Explore
erythrocyte	8 studies	36% ± 13%	Explore
endothelial cell of artery	8 studies	20% ± 3%	Explore
connective tissue cell	8 studies	21% ± 4%	Explore
club cell	7 studies	53% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	24% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	25% ± 4%	Explore
CD8-positive, alpha-beta T cell	7 studies	21% ± 5%	Explore
mature NK T cell	7 studies	20% ± 3%	Explore
capillary endothelial cell	7 studies	20% ± 4%	Explore
dendritic cell	7 studies	43% ± 25%	Explore
T cell	6 studies	20% ± 3%	Explore
type I pneumocyte	6 studies	30% ± 13%	Explore
plasmablast	6 studies	42% ± 23%	Explore
ionocyte	6 studies	35% ± 11%	Explore
respiratory goblet cell	6 studies	58% ± 17%	Explore
naive B cell	6 studies	19% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	20% ± 4%	Explore
CD4-positive, alpha-beta T cell	6 studies	20% ± 6%	Explore
vein endothelial cell	6 studies	20% ± 5%	Explore
abnormal cell	6 studies	22% ± 4%	Explore
myeloid cell	6 studies	28% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	21% ± 5%	Explore
epithelial cell of proximal tubule	5 studies	23% ± 4%	Explore
kidney loop of Henle epithelial cell	5 studies	35% ± 3%	Explore
intestinal crypt stem cell	5 studies	22% ± 7%	Explore
transit amplifying cell	5 studies	22% ± 7%	Explore
precursor B cell	5 studies	23% ± 4%	Explore
regulatory T cell	5 studies	19% ± 3%	Explore
pancreatic A cell	4 studies	45% ± 14%	Explore
leukocyte	4 studies	27% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	20% ± 3%	Explore
mononuclear phagocyte	4 studies	26% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	24% ± 4%	Explore
retinal cone cell	4 studies	62% ± 27%	Explore
myofibroblast cell	4 studies	25% ± 7%	Explore
neuron	4 studies	40% ± 16%	Explore
retinal rod cell	4 studies	35% ± 18%	Explore
type II pneumocyte	4 studies	29% ± 12%	Explore
innate lymphoid cell	4 studies	22% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	52% ± 7%	Explore
memory B cell	4 studies	18% ± 3%	Explore
mast cell	4 studies	20% ± 5%	Explore
enteroendocrine cell	4 studies	32% ± 15%	Explore
hematopoietic precursor cell	3 studies	45% ± 16%	Explore
duct epithelial cell	3 studies	60% ± 8%	Explore
squamous epithelial cell	3 studies	58% ± 17%	Explore
type B pancreatic cell	3 studies	45% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
renal alpha-intercalated cell	3 studies	35% ± 5%	Explore
neural crest cell	3 studies	19% ± 1%	Explore
retinal bipolar neuron	3 studies	40% ± 16%	Explore
erythroblast	3 studies	39% ± 23%	Explore
hematopoietic stem cell	3 studies	20% ± 4%	Explore
lymphocyte	3 studies	33% ± 8%	Explore
mucosal invariant T cell	3 studies	17% ± 1%	Explore
neuroendocrine cell	3 studies	43% ± 16%	Explore
enterocyte	3 studies	23% ± 5%	Explore
progenitor cell	3 studies	24% ± 2%	Explore
retina horizontal cell	3 studies	30% ± 12%	Explore
mucus secreting cell	3 studies	46% ± 15%	Explore
serous secreting cell	3 studies	32% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	25% ± 7%	Explore
luminal cell of prostate epithelium	3 studies	43% ± 12%	Explore
pancreatic ductal cell	3 studies	32% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	34% ± 26%	Explore
keratinocyte	3 studies	53% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	18% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	13 studies	32% ± 18%	Explore
peripheral blood	11 studies	25% ± 11%	Explore
eye	7 studies	28% ± 15%	Explore
kidney	6 studies	21% ± 6%	Explore
intestine	5 studies	24% ± 7%	Explore
pancreas	4 studies	40% ± 19%	Explore
uterus	4 studies	26% ± 16%	Explore
breast	4 studies	25% ± 4%	Explore
bone marrow	3 studies	17% ± 0%	Explore
prostate	3 studies	38% ± 12%	Explore
brain	3 studies	18% ± 2%	Explore
liver	3 studies	34% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5200.90	1445 / 1445	100%	31.31	183 / 183
intestine	100%	5114.94	966 / 966	100%	43.46	527 / 527
stomach	100%	4186.68	359 / 359	100%	34.36	286 / 286
uterus	100%	2630.86	170 / 170	100%	56.48	459 / 459
bladder	100%	5610.43	21 / 21	100%	46.96	503 / 504
prostate	100%	4895.95	245 / 245	100%	45.30	501 / 502
brain	100%	3785.78	2636 / 2642	100%	35.88	705 / 705
thymus	100%	3972.77	652 / 653	100%	48.51	604 / 605
lung	100%	4478.70	576 / 578	100%	39.66	1155 / 1155
breast	100%	3940.92	459 / 459	100%	50.83	1113 / 1118
pancreas	99%	2568.86	325 / 328	100%	42.16	178 / 178
kidney	100%	5642.83	89 / 89	99%	32.65	890 / 901
ovary	99%	2353.74	179 / 180	99%	26.25	427 / 430
adrenal gland	100%	3325.76	258 / 258	98%	36.39	226 / 230
liver	100%	2138.71	225 / 226	99%	21.29	400 / 406
skin	100%	6533.62	1807 / 1809	98%	24.26	461 / 472
adipose	100%	3812.49	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	42.23	29 / 29
muscle	100%	7811.12	803 / 803	0%	0	0 / 0
peripheral blood	100%	5463.95	929 / 929	0%	0	0 / 0
spleen	100%	3340.52	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	44.52	45 / 45
ureter	0%	0	0 / 0	100%	106.85	1 / 1
blood vessel	100%	3695.31	1333 / 1335	0%	0	0 / 0
heart	98%	5258.14	846 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	93%	20.41	74 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006915	Biological process	apoptotic process
GO_0034393	Biological process	positive regulation of smooth muscle cell apoptotic process
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0051085	Biological process	chaperone cofactor-dependent protein refolding
GO_0050821	Biological process	protein stabilization
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0005515	Molecular function	protein binding
GO_0000774	Molecular function	adenyl-nucleotide exchange factor activity

IV. Literature review

[source]

Gene name	BAG1
Protein name	BCL2-associated athanogene isoform 2 (BCL2-associated athanogene, isoform CRA_c) BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1) BAG family molecular chaperone regulator 1 BAG cochaperone 1
Synonyms	HAP hCG_30265
Description	FUNCTION: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 . Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity . Markedly increases the anti-cell death function of BCL2 induced by various stimuli . Involved in the STUB1-mediated proteasomal degradation of ESR1 in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity). .
Accessions	ENST00000473464.2 Q99933 ENST00000379704.7 [Q99933-4] ENST00000634734 A0A0S2Z3F5 A0A0U1RR89 C9J9Y9 ENST00000488499.1 A0A0S2Z3K4 ENST00000379707.7 J3QTA2 ENST00000473781.1 F1LLU6 ENST00000634734.3 [Q99933-1] C9JYK5

BAG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review