C1QBP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_0030449Biological processregulation of complement activation
GO_0045087Biological processinnate immune response
GO_1901165Biological processpositive regulation of trophoblast cell migration
GO_0006974Biological processDNA damage response
GO_0032695Biological processnegative regulation of interleukin-12 production
GO_0045785Biological processpositive regulation of cell adhesion
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0039536Biological processnegative regulation of RIG-I signaling pathway
GO_0039534Biological processnegative regulation of MDA-5 signaling pathway
GO_0006955Biological processimmune response
GO_2000510Biological processpositive regulation of dendritic cell chemotaxis
GO_0008380Biological processRNA splicing
GO_0006958Biological processcomplement activation, classical pathway
GO_0050687Biological processnegative regulation of defense response to virus
GO_0042256Biological processcytosolic ribosome assembly
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0090023Biological processpositive regulation of neutrophil chemotaxis
GO_0006915Biological processapoptotic process
GO_0070131Biological processpositive regulation of mitochondrial translation
GO_0032689Biological processnegative regulation of type II interferon production
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1900026Biological processpositive regulation of substrate adhesion-dependent cell spreading
GO_0048025Biological processnegative regulation of mRNA splicing, via spliceosome
GO_0043065Biological processpositive regulation of apoptotic process
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0005730Cellular componentnucleolus
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0030984Molecular functionkininogen binding
GO_0004857Molecular functionenzyme inhibitor activity
GO_0031690Molecular functionadrenergic receptor binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0003729Molecular functionmRNA binding
GO_0097177Molecular functionmitochondrial ribosome binding
GO_0001849Molecular functioncomplement component C1q complex binding
GO_0060703Molecular functiondeoxyribonuclease inhibitor activity
GO_0005515Molecular functionprotein binding
GO_0005540Molecular functionhyaluronic acid binding

IV. Literature review

[source]
Gene nameC1QBP
Protein nameComplement C1q binding protein
Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32)
Complement component 1 Q subcomponent-binding protein, mitochondrial
SynonymsSF2P32
GC1QBP
hCG_2040042
HABP1
DescriptionFUNCTION: Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria . In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection. .; FUNCTION: (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. .; FUNCTION: (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. .; FUNCTION: (Microbial infection) Involved in replication of Rubella virus. .

AccessionsENST00000576122.1
ENST00000574444.5
A0A0G2JLC0
I3L3Q7
ENST00000570805.1
ENST00000225698.8
I3L3B0
Q07021