TP63 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TP63 at tissue level.

III. Associated gene sets

GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0060197Biological processcloacal septation
GO_0006366Biological processtranscription by RNA polymerase II
GO_0030216Biological processkeratinocyte differentiation
GO_1904888Biological processcranial skeletal system development
GO_0048807Biological processfemale genitalia morphogenesis
GO_0060529Biological processsquamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO_0009954Biological processproximal/distal pattern formation
GO_0007283Biological processspermatogenesis
GO_0007219Biological processNotch signaling pathway
GO_0048485Biological processsympathetic nervous system development
GO_0061436Biological processestablishment of skin barrier
GO_0008340Biological processdetermination of adult lifespan
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0031069Biological processhair follicle morphogenesis
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0060513Biological processprostatic bud formation
GO_0007499Biological processectoderm and mesoderm interaction
GO_2000648Biological processpositive regulation of stem cell proliferation
GO_0072089Biological processstem cell proliferation
GO_0010838Biological processpositive regulation of keratinocyte proliferation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0006338Biological processchromatin remodeling
GO_0035115Biological processembryonic forelimb morphogenesis
GO_0033147Biological processnegative regulation of intracellular estrogen receptor signaling pathway
GO_0035116Biological processembryonic hindlimb morphogenesis
GO_0010482Biological processregulation of epidermal cell division
GO_0051262Biological processprotein tetramerization
GO_0045617Biological processnegative regulation of keratinocyte differentiation
GO_0051402Biological processneuron apoptotic process
GO_2000271Biological processpositive regulation of fibroblast apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0036342Biological processpost-anal tail morphogenesis
GO_2000381Biological processnegative regulation of mesoderm development
GO_0010481Biological processepidermal cell division
GO_0043589Biological processskin morphogenesis
GO_0006915Biological processapoptotic process
GO_0001501Biological processskeletal system development
GO_1904674Biological processpositive regulation of somatic stem cell population maintenance
GO_0090398Biological processcellular senescence
GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0043616Biological processkeratinocyte proliferation
GO_0002064Biological processepithelial cell development
GO_0001736Biological processestablishment of planar polarity
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0030859Biological processpolarized epithelial cell differentiation
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003684Molecular functiondamaged DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0050699Molecular functionWW domain binding
GO_0097371Molecular functionMDM2/MDM4 family protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046872Molecular functionmetal ion binding
GO_0002039Molecular functionp53 binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTP63
Protein nameCellular tumor antigen p53
Tumor protein p63
Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)
Tumor protein 63 (p63)
SynonymsP73L
P73H
KET
hCG_16028
P63
TP73L
DescriptionFUNCTION: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. .

FUNCTION: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. .

FUNCTION: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. .

FUNCTION: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. .

FUNCTION: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. .

FUNCTION: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. .

FUNCTION: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. .

AccessionsA0A0S2Z4N6
ENST00000320472.9 [Q9H3D4-7]
A0A0S2Z4N5
ENST00000264731.8 [Q9H3D4-1]
C9JW72
C9D7D0
ENST00000434928.5
ENST00000449992.5 [Q9H3D4-10]
A0A141PNN4
ENST00000354600.10 [Q9H3D4-2]
ENST00000456148.1 [Q9H3D4-12]
ENST00000437221.5 [Q9H3D4-6]
Q9H3D4
ENST00000392461.7 [Q9H3D4-8]
ENST00000440651.6 [Q9H3D4-11]
ENST00000392460.7 [Q9H3D4-3]
ENST00000418709.6 [Q9H3D4-5]
A0A141PNN3
C9D7C9
ENST00000392463.6 [Q9H3D4-4]