PUF60 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0006376Biological processmRNA splice site recognition
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0000380Biological processalternative mRNA splicing, via spliceosome
GO_0030054Cellular componentcell junction
GO_0005654Cellular componentnucleoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0045296Molecular functioncadherin binding
GO_0003677Molecular functionDNA binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene namePUF60
Protein namePoly(U) binding splicing factor 60
Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor)
Fuse-binding protein-interacting repressor, isoform CRA_h (Poly(U) binding splicing factor 60)
Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)
SynonymsFIR
SIAHBP1
hCG_40718
ROBPI
DescriptionFUNCTION: DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. .

AccessionsA0A994J6K6
ENST00000703849.1 [Q9UHX1-3]
ENST00000456095.6 [Q9UHX1-5]
ENST00000531897.5
ENST00000529999.5
ENST00000349157.10 [Q9UHX1-2]
ENST00000703847.1
A0A994J6L7
H0YEM1
ENST00000533162.2
ENST00000313352.11 [Q9UHX1-4]
E9PMU7
Q9UHX1
ENST00000527197.5 [Q9UHX1-6]
ENST00000533362.2
ENST00000532127.6
E9PQ56
E9PL19
ENST00000527744.6
ENST00000526459.6
A0A994J4J5
ENST00000703846.1 [Q9UHX1-3]
ENST00000703850.1
ENST00000531951.6 [Q9UHX1-3]
ENST00000703866.1 [Q9UHX1-1]
ENST00000526683.6 [Q9UHX1-1]
ENST00000532884.1
ENST00000453551.6 [Q9UHX1-3]
E9PN18
H0YCP8
ENST00000703852.1