CEACAM6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_2000811Biological processnegative regulation of anoikis
GO_0030335Biological processpositive regulation of cell migration
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0034116Biological processpositive regulation of heterotypic cell-cell adhesion
GO_0006915Biological processapoptotic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_1904906Biological processpositive regulation of endothelial cell-matrix adhesion via fibronectin
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0016324Cellular componentapical plasma membrane
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0035577Cellular componentazurophil granule membrane
GO_0009986Cellular componentcell surface
GO_0098552Cellular componentside of membrane
GO_0042802Molecular functionidentical protein binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCEACAM6
Protein nameCEA cell adhesion molecule 6
Carcinoembryonic antigen-related cell adhesion molecule 6 (Non-specific crossreacting antigen) (Normal cross-reacting antigen) (CD antigen CD66c)
SynonymsNCA
DescriptionFUNCTION: Cell surface glycoprotein that plays a role in cell adhesion and tumor progression . Intercellular adhesion occurs in a calcium- and fibronectin-independent manner . Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 . Heterophilic interaction with CEACAM8 occurs in activated neutrophils . Plays a role in neutrophil adhesion to cytokine-activated endothelial cells . Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion . Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells . .

AccessionsM0QYD3
ENST00000199764.7
ENST00000595740.1
P40199