SLC5A8 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC5A8 at tissue level.

III. Associated gene sets

GO_0015730Biological processpropanoate transmembrane transport
GO_0006821Biological processchloride transport
GO_0034356Biological processNAD biosynthesis via nicotinamide riboside salvage pathway
GO_0006848Biological processpyruvate transport
GO_0006811Biological processmonoatomic ion transport
GO_0015727Biological processlactate transport
GO_0015705Biological processiodide transport
GO_0006846Biological processacetate transport
GO_0015706Biological processnitrate transmembrane transport
GO_2001142Biological processnicotinate transport
GO_0006814Biological processsodium ion transport
GO_0006915Biological processapoptotic process
GO_0035873Biological processlactate transmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0000811Cellular componentGINS complex
GO_0022803Molecular functionpassive transmembrane transporter activity
GO_0015129Molecular functionlactate transmembrane transporter activity
GO_0005343Molecular functionorganic acid:sodium symporter activity
GO_0015552Molecular functionpropionate transmembrane transporter activity
GO_0008028Molecular functionmonocarboxylic acid transmembrane transporter activity
GO_0140161Molecular functionmonocarboxylate:sodium symporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC5A8
Protein nameSodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8)
SynonymsSMCT1
SMCT
AIT
DescriptionFUNCTION: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1 . Catalyzes passive carrier mediated diffusion of iodide . Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane . May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract . Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines . May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons . Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline) . Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced . .

AccessionsENST00000572861.3
ENST00000536262.3
Q8N695