YARS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	20 studies	22% ± 6%	Explore
CD8-positive, alpha-beta T cell	11 studies	21% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	26% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	24% ± 7%	Explore
gamma-delta T cell	7 studies	22% ± 9%	Explore
mature NK T cell	6 studies	21% ± 8%	Explore
endothelial cell	6 studies	24% ± 6%	Explore
glutamatergic neuron	6 studies	37% ± 22%	Explore
epithelial cell	6 studies	27% ± 8%	Explore
hematopoietic precursor cell	5 studies	22% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	20% ± 3%	Explore
CD4-positive, alpha-beta T cell	5 studies	20% ± 4%	Explore
adipocyte	5 studies	24% ± 6%	Explore
astrocyte	5 studies	25% ± 8%	Explore
macrophage	5 studies	18% ± 2%	Explore
type II pneumocyte	5 studies	28% ± 10%	Explore
mucosal invariant T cell	5 studies	16% ± 1%	Explore
regulatory T cell	5 studies	20% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	19% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	21% ± 2%	Explore
exhausted T cell	4 studies	23% ± 5%	Explore
neuron	4 studies	23% ± 6%	Explore
ciliated cell	4 studies	18% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	24% ± 8%	Explore
basal cell	4 studies	31% ± 9%	Explore
GABAergic neuron	4 studies	41% ± 16%	Explore
goblet cell	4 studies	24% ± 10%	Explore
oligodendrocyte	4 studies	21% ± 5%	Explore
plasmablast	3 studies	36% ± 17%	Explore
retinal ganglion cell	3 studies	54% ± 18%	Explore
fibroblast	3 studies	22% ± 4%	Explore
endothelial cell of lymphatic vessel	3 studies	28% ± 9%	Explore
mast cell	3 studies	24% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
dendritic cell	3 studies	27% ± 6%	Explore
abnormal cell	3 studies	23% ± 3%	Explore
granulocyte monocyte progenitor cell	3 studies	20% ± 0%	Explore
T cell	3 studies	22% ± 5%	Explore
transit amplifying cell	3 studies	26% ± 12%	Explore
interneuron	3 studies	39% ± 18%	Explore
erythroblast	3 studies	23% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	16% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	5 studies	19% ± 3%	Explore
lung	5 studies	18% ± 2%	Explore
brain	5 studies	36% ± 13%	Explore
liver	3 studies	25% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	3732.48	966 / 966	100%	39.50	527 / 527
lung	100%	6709.71	578 / 578	100%	40.29	1155 / 1155
ovary	100%	3376.47	180 / 180	100%	28.70	430 / 430
pancreas	100%	3650.66	328 / 328	100%	27.87	178 / 178
stomach	100%	4929.06	359 / 359	100%	35.01	286 / 286
uterus	100%	3454.12	170 / 170	100%	45.40	459 / 459
skin	100%	7251.33	1808 / 1809	100%	43.96	472 / 472
esophagus	100%	4395.82	1444 / 1445	100%	32.41	183 / 183
thymus	100%	4308.62	653 / 653	100%	31.62	603 / 605
breast	100%	4466.09	459 / 459	100%	36.33	1114 / 1118
bladder	100%	4565.14	21 / 21	100%	39.39	502 / 504
prostate	100%	3680.74	244 / 245	100%	29.44	501 / 502
brain	99%	5713.48	2615 / 2642	100%	37.74	705 / 705
liver	100%	4202.99	226 / 226	99%	22.86	401 / 406
kidney	100%	2933.75	89 / 89	98%	19.27	886 / 901
adrenal gland	100%	8537.00	258 / 258	97%	25.72	223 / 230
adipose	100%	4599.99	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	29.31	80 / 80
lymph node	0%	0	0 / 0	100%	43.56	29 / 29
spleen	100%	4350.97	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	43.69	45 / 45
ureter	0%	0	0 / 0	100%	13.32	1 / 1
blood vessel	100%	3487.90	1331 / 1335	0%	0	0 / 0
muscle	100%	4415.31	800 / 803	0%	0	0 / 0
peripheral blood	94%	5040.19	877 / 929	0%	0	0 / 0
heart	93%	2598.22	802 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006915	Biological process	apoptotic process
GO_0042594	Biological process	response to starvation
GO_0006437	Biological process	tyrosyl-tRNA aminoacylation
GO_0005615	Cellular component	extracellular space
GO_0016604	Cellular component	nuclear body
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0036094	Molecular function	small molecule binding
GO_0005153	Molecular function	interleukin-8 receptor binding
GO_0000049	Molecular function	tRNA binding
GO_0005515	Molecular function	protein binding
GO_0004831	Molecular function	tyrosine-tRNA ligase activity
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	YARS1
Protein name	Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed] Tyrosyl-tRNA synthetase isoform 2 Tyrosyl-tRNA synthetase 1 tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase)
Synonyms	YARS
Description	FUNCTION: Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable) . Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity . Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1 . .
Accessions	A0A6Q8PF15 A0A6Q8PFX2 ENST00000676297.1 ENST00000675785.2 A0A6Q8PFX4 ENST00000616261.2 A0A6Q8PGW2 A0A0S2Z4R1 A0A0C4DGZ5 ENST00000373477.9 ENST00000481895.6 ENST00000674654.1 A0A0S2Z4P3 ENST00000674629.1 A0A6Q8PFC1 P54577

YARS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review