SEMA6A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001755Biological processneural crest cell migration
GO_0009887Biological processanimal organ morphogenesis
GO_2001224Biological processpositive regulation of neuron migration
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_1903671Biological processnegative regulation of sprouting angiogenesis
GO_0007010Biological processcytoskeleton organization
GO_0050919Biological processnegative chemotaxis
GO_0016525Biological processnegative regulation of angiogenesis
GO_0106089Biological processnegative regulation of cell adhesion involved in sprouting angiogenesis
GO_1900747Biological processnegative regulation of vascular endothelial growth factor signaling pathway
GO_0006915Biological processapoptotic process
GO_0071526Biological processsemaphorin-plexin signaling pathway
GO_0035924Biological processcellular response to vascular endothelial growth factor stimulus
GO_0007399Biological processnervous system development
GO_0007411Biological processaxon guidance
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0030424Cellular componentaxon
GO_0030215Molecular functionsemaphorin receptor binding
GO_0045499Molecular functionchemorepellent activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSEMA6A
Protein nameSemaphorin 6A
Sema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6A, isoform CRA_d (Semaphorin-6A)
Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1)
Semaphorin 6A (cDNA FLJ39018 fis, clone NT2RP7002594, highly similar to Semaphorin-6A)
SynonymshCG_2028216
SEMAQ
KIAA1368
DescriptionFUNCTION: Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. .; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. .

AccessionsENST00000515129.5
A0A0A0MQU6
ENST00000510263.5 [Q9H2E6-1]
ENST00000343348.11 [Q9H2E6-1]
ENST00000257414.12 [Q9H2E6-2]
ENST00000503865.1
H0Y8V9
ENST00000513137.5
D6RAG9
ENST00000515009.5
ENST00000509665.1
D6RCR0
ENST00000257414
B3KU01
E9PDV9
Q9H2E6