TCIM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903706Biological processregulation of hemopoiesis
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0034605Biological processcellular response to heat
GO_1902806Biological processregulation of cell cycle G1/S phase transition
GO_0043066Biological processnegative regulation of apoptotic process
GO_0010739Biological processpositive regulation of protein kinase A signaling
GO_1900020Biological processpositive regulation of protein kinase C activity
GO_0006915Biological processapoptotic process
GO_0002264Biological processendothelial cell activation involved in immune response
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005112Molecular functionNotch binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTCIM
Protein nameTranscriptional and immune response regulator (Thyroid cancer protein 1) (TC-1)
Alternative protein C8orf4
SynonymsC8orf4
TC1
DescriptionFUNCTION: Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 . Enhances the proliferation of follicular dendritic cells . Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle . In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity . Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression . Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis . However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling . .

AccessionsQ9NR00
ENST00000315792.5
L8E8Y4