CHIA | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHIA at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	77%	28.10	503 / 653	37%	1.11	221 / 605
lung	78%	268.20	449 / 578	30%	3.88	351 / 1155
stomach	84%	11969.40	300 / 359	2%	0.09	7 / 286
adipose	23%	19.95	274 / 1204	0%	0	0 / 0
kidney	20%	4.21	18 / 89	2%	0.06	18 / 901
breast	10%	5.86	47 / 459	1%	0.05	13 / 1118
liver	10%	2.36	22 / 226	1%	0.03	4 / 406
peripheral blood	10%	3.67	90 / 929	0%	0	0 / 0
uterus	6%	1.75	11 / 170	1%	0.03	6 / 459
lymph node	0%	0	0 / 0	7%	0.11	2 / 29
adrenal gland	6%	2.45	16 / 258	0%	0	0 / 230
esophagus	3%	55.85	49 / 1445	3%	3.13	5 / 183
spleen	5%	0.85	13 / 241	0%	0	0 / 0
ovary	4%	2.11	7 / 180	1%	0.04	4 / 430
bladder	0%	0	0 / 21	5%	0.40	23 / 504
intestine	3%	0.50	29 / 966	2%	2.52	8 / 527
heart	4%	1.98	35 / 861	0%	0	0 / 0
blood vessel	3%	0.94	45 / 1335	0%	0	0 / 0
skin	3%	0.77	49 / 1809	0%	0.00	1 / 472
prostate	3%	0.82	7 / 245	0%	0	0 / 502
pancreas	1%	0.18	4 / 328	1%	0.02	2 / 178
brain	2%	0.29	45 / 2642	0%	0.01	2 / 705
muscle	2%	0.27	14 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006030	Biological process	chitin metabolic process
GO_0006915	Biological process	apoptotic process
GO_0032722	Biological process	positive regulation of chemokine production
GO_0002376	Biological process	immune system process
GO_0002532	Biological process	production of molecular mediator involved in inflammatory response
GO_0000272	Biological process	polysaccharide catabolic process
GO_0006032	Biological process	chitin catabolic process
GO_0044245	Biological process	polysaccharide digestion
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005737	Cellular component	cytoplasm
GO_0019900	Molecular function	kinase binding
GO_0005515	Molecular function	protein binding
GO_0004568	Molecular function	chitinase activity
GO_0008061	Molecular function	chitin binding

Gene name	CHIA
Protein name	Chitinase acidic Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902) chitinase (EC 3.2.1.14)
Synonyms
Description	FUNCTION: Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. .
Accessions	ENST00000430615.1 [Q9BZP6-2] ENST00000422815.5 ENST00000451398.6 [Q9BZP6-3] E9PLJ2 ENST00000483391.5 [Q9BZP6-3] A5D6V7 ENST00000352594.10 ENST00000489524.5 Q5VUV5 H7BXH6 ENST00000353665.10 [Q9BZP6-3] ENST00000343320.10 [Q9BZP6-1] Q9BZP6 ENST00000369740.6 [Q9BZP6-1]

CHIA report