PPP1R15A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	36 studies	51% ± 19%	Explore
natural killer cell	36 studies	44% ± 19%	Explore
fibroblast	35 studies	55% ± 20%	Explore
macrophage	32 studies	54% ± 18%	Explore
endothelial cell	31 studies	54% ± 23%	Explore
CD8-positive, alpha-beta T cell	31 studies	40% ± 16%	Explore
pericyte	29 studies	62% ± 23%	Explore
conventional dendritic cell	28 studies	59% ± 18%	Explore
CD4-positive, alpha-beta T cell	28 studies	44% ± 21%	Explore
classical monocyte	27 studies	57% ± 20%	Explore
T cell	25 studies	43% ± 21%	Explore
mast cell	24 studies	65% ± 21%	Explore
non-classical monocyte	24 studies	54% ± 21%	Explore
plasmacytoid dendritic cell	24 studies	64% ± 19%	Explore
regulatory T cell	24 studies	45% ± 21%	Explore
smooth muscle cell	23 studies	57% ± 23%	Explore
dendritic cell	22 studies	57% ± 23%	Explore
monocyte	21 studies	50% ± 18%	Explore
memory B cell	20 studies	53% ± 20%	Explore
basal cell	20 studies	53% ± 16%	Explore
endothelial cell of lymphatic vessel	19 studies	54% ± 21%	Explore
epithelial cell	19 studies	51% ± 20%	Explore
plasma cell	18 studies	45% ± 18%	Explore
ciliated cell	18 studies	52% ± 21%	Explore
mature NK T cell	18 studies	43% ± 15%	Explore
naive B cell	18 studies	45% ± 18%	Explore
gamma-delta T cell	17 studies	47% ± 21%	Explore
connective tissue cell	17 studies	53% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	49% ± 25%	Explore
mucosal invariant T cell	13 studies	49% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	32% ± 15%	Explore
neutrophil	13 studies	50% ± 24%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	46% ± 21%	Explore
myofibroblast cell	13 studies	53% ± 24%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	37% ± 17%	Explore
capillary endothelial cell	12 studies	44% ± 15%	Explore
endothelial cell of vascular tree	12 studies	65% ± 14%	Explore
innate lymphoid cell	11 studies	52% ± 16%	Explore
vein endothelial cell	11 studies	40% ± 17%	Explore
myeloid cell	11 studies	57% ± 21%	Explore
secretory cell	11 studies	54% ± 15%	Explore
endothelial cell of artery	10 studies	42% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	47% ± 15%	Explore
plasmablast	9 studies	47% ± 17%	Explore
platelet	9 studies	29% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	51% ± 24%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	50% ± 21%	Explore
type I pneumocyte	8 studies	51% ± 20%	Explore
type II pneumocyte	8 studies	38% ± 20%	Explore
leukocyte	8 studies	57% ± 18%	Explore
abnormal cell	8 studies	46% ± 22%	Explore
goblet cell	8 studies	28% ± 9%	Explore
erythrocyte	8 studies	36% ± 21%	Explore
alveolar macrophage	7 studies	37% ± 13%	Explore
progenitor cell	7 studies	39% ± 16%	Explore
IgA plasma cell	7 studies	35% ± 11%	Explore
IgG plasma cell	7 studies	31% ± 9%	Explore
CD4-positive helper T cell	6 studies	46% ± 22%	Explore
club cell	6 studies	36% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	29% ± 13%	Explore
mononuclear phagocyte	6 studies	50% ± 19%	Explore
hematopoietic stem cell	6 studies	44% ± 14%	Explore
precursor B cell	6 studies	49% ± 12%	Explore
enterocyte	6 studies	25% ± 9%	Explore
immature B cell	6 studies	58% ± 11%	Explore
mesothelial cell	6 studies	47% ± 29%	Explore
T follicular helper cell	6 studies	54% ± 27%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	37% ± 8%	Explore
hematopoietic precursor cell	5 studies	50% ± 15%	Explore
pro-B cell	5 studies	38% ± 9%	Explore
group 3 innate lymphoid cell	5 studies	78% ± 16%	Explore
granulocyte	5 studies	61% ± 9%	Explore
deuterosomal cell	4 studies	25% ± 4%	Explore
squamous epithelial cell	4 studies	54% ± 22%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	48% ± 16%	Explore
microglial cell	4 studies	43% ± 22%	Explore
T-helper 17 cell	4 studies	68% ± 20%	Explore
adventitial cell	4 studies	46% ± 16%	Explore
erythroblast	4 studies	38% ± 21%	Explore
intermediate monocyte	4 studies	71% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	49% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	60% ± 15%	Explore
glial cell	4 studies	31% ± 6%	Explore
keratinocyte	4 studies	59% ± 23%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	42% ± 6%	Explore
precursor cell	3 studies	46% ± 12%	Explore
pancreatic A cell	3 studies	33% ± 2%	Explore
monocyte-derived dendritic cell	3 studies	71% ± 21%	Explore
exhausted T cell	3 studies	30% ± 8%	Explore
glomerular endothelial cell	3 studies	61% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	37% ± 4%	Explore
astrocyte	3 studies	43% ± 5%	Explore
kidney loop of Henle epithelial cell	3 studies	31% ± 8%	Explore
extravillous trophoblast	3 studies	36% ± 6%	Explore
placental villous trophoblast	3 studies	20% ± 3%	Explore
lymphocyte	3 studies	56% ± 25%	Explore
megakaryocyte	3 studies	43% ± 10%	Explore
ionocyte	3 studies	28% ± 3%	Explore
Schwann cell	3 studies	74% ± 11%	Explore
neuron	3 studies	37% ± 14%	Explore
intraepithelial lymphocyte	3 studies	28% ± 14%	Explore
inflammatory macrophage	3 studies	53% ± 28%	Explore
respiratory goblet cell	3 studies	40% ± 7%	Explore
germinal center B cell	3 studies	31% ± 7%	Explore
luminal cell of prostate epithelium	3 studies	60% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	60% ± 13%	Explore
enteroendocrine cell	3 studies	29% ± 6%	Explore
melanocyte	3 studies	59% ± 19%	Explore
double negative thymocyte	3 studies	52% ± 20%	Explore
double-positive, alpha-beta thymocyte	3 studies	54% ± 24%	Explore
progenitor cell of mammary luminal epithelium	3 studies	66% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	44% ± 15%	Explore
peripheral blood	16 studies	46% ± 18%	Explore
intestine	10 studies	44% ± 22%	Explore
kidney	7 studies	41% ± 18%	Explore
liver	6 studies	28% ± 14%	Explore
uterus	5 studies	65% ± 19%	Explore
lymph node	5 studies	43% ± 21%	Explore
placenta	4 studies	31% ± 11%	Explore
bone marrow	4 studies	32% ± 11%	Explore
prostate	4 studies	57% ± 13%	Explore
skin	4 studies	59% ± 8%	Explore
breast	4 studies	62% ± 9%	Explore
pancreas	3 studies	28% ± 6%	Explore
eye	3 studies	39% ± 25%	Explore
adrenal gland	3 studies	43% ± 18%	Explore
esophagus	3 studies	45% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	100%	14536.89	1809 / 1809	100%	127.60	472 / 472
uterus	100%	10490.60	170 / 170	100%	130.74	457 / 459
bladder	100%	12253.81	21 / 21	99%	126.69	500 / 504
lung	100%	23654.69	577 / 578	99%	94.69	1145 / 1155
esophagus	98%	7778.39	1417 / 1445	100%	113.70	183 / 183
intestine	97%	7425.55	941 / 966	100%	96.87	525 / 527
breast	99%	10990.40	455 / 459	97%	65.14	1089 / 1118
prostate	97%	6628.06	237 / 245	99%	108.62	499 / 502
kidney	97%	8973.53	86 / 89	99%	102.88	896 / 901
ovary	100%	9877.05	180 / 180	96%	47.21	412 / 430
thymus	96%	7898.67	624 / 653	99%	99.84	599 / 605
adrenal gland	95%	6660.82	245 / 258	99%	94.39	227 / 230
stomach	86%	7215.21	307 / 359	99%	82.39	284 / 286
brain	59%	3566.58	1568 / 2642	91%	45.99	645 / 705
liver	65%	4054.61	146 / 226	79%	42.21	322 / 406
pancreas	23%	945.09	74 / 328	99%	136.90	177 / 178
eye	0%	0	0 / 0	100%	78.24	80 / 80
spleen	100%	7276.85	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	114.45	45 / 45
ureter	0%	0	0 / 0	100%	91.11	1 / 1
adipose	100%	16216.14	1202 / 1204	0%	0	0 / 0
blood vessel	100%	13402.38	1331 / 1335	0%	0	0 / 0
peripheral blood	99%	18926.15	923 / 929	0%	0	0 / 0
heart	98%	11424.46	840 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	60.53	28 / 29
muscle	93%	5550.95	746 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0070059	Biological process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_0032515	Biological process	negative regulation of phosphoprotein phosphatase activity
GO_1902310	Biological process	positive regulation of peptidyl-serine dephosphorylation
GO_0006974	Biological process	DNA damage response
GO_0070972	Biological process	protein localization to endoplasmic reticulum
GO_0036496	Biological process	regulation of translational initiation by eIF2 alpha dephosphorylation
GO_1903898	Biological process	negative regulation of PERK-mediated unfolded protein response
GO_0006915	Biological process	apoptotic process
GO_0032516	Biological process	positive regulation of phosphoprotein phosphatase activity
GO_1903917	Biological process	positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
GO_0032058	Biological process	positive regulation of translational initiation in response to stress
GO_0035308	Biological process	negative regulation of protein dephosphorylation
GO_0051726	Biological process	regulation of cell cycle
GO_0000164	Cellular component	protein phosphatase type 1 complex
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005739	Cellular component	mitochondrion
GO_0005794	Cellular component	Golgi apparatus
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0019901	Molecular function	protein kinase binding
GO_0008157	Molecular function	protein phosphatase 1 binding
GO_0072542	Molecular function	protein phosphatase activator activity
GO_0019888	Molecular function	protein phosphatase regulator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PPP1R15A
Protein name	Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) Protein phosphatase 1 regulatory subunit 15A Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog)
Synonyms	GADD34
Description	FUNCTION: Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress . Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1 . May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15' . Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux . Acts also a viral restriction factor by attenuating HIV-1 replication . Mechanistically, mediates the inhibition of HIV-1 TAR RNA-mediated translation . .; FUNCTION: (Microbial infection) Promotes enterovirus 71 replication by mediating the internal ribosome entry site (IRES) activity of viral 5'-UTR. .
Accessions	ENST00000704026.1 A0A994J4D6 A0A994J786 ENST00000200453.6 [O75807-1] ENST00000704027.1 ENST00000600406.2 O75807 M0QXL1

PPP1R15A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review