FEM1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060743Biological processepithelial cell maturation involved in prostate gland development
GO_0006915Biological processapoptotic process
GO_0060442Biological processbranching involved in prostate gland morphogenesis
GO_0016567Biological processprotein ubiquitination
GO_0051438Biological processregulation of ubiquitin-protein transferase activity
GO_2000001Biological processregulation of DNA damage checkpoint
GO_1902041Biological processregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0140627Biological processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0005123Molecular functiondeath receptor binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameFEM1B
Protein nameProtein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha)
Fem-1 homolog B
SynonymsF1AA
KIAA0396
DescriptionFUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, such as CDK5R1, leading to their ubiquitination and degradation . Also acts as a regulator of the reductive stress response by mediating ubiquitination of reduced FNIP1: in response to reductive stress, the CRL2(FEM1B) complex specifically recognizes a conserved Cys degron in FNIP1 when this degron is reduced, leading to FNIP1 degradation and subsequent activation of mitochondria to recalibrate reactive oxygen species (ROS) (By similarity). Mechanistically, recognizes and binds reduced FNIP1 through two interface zinc ions, which act as a molecular glue that recruit reduced FNIP1 to FEM1B (By similarity). Promotes ubiquitination of GLI1, suppressing GLI1 transcriptional activator activity . Promotes ubiquitination and degradation of ANKRD37 (By similarity). Promotes ubiquitination and degradation of SLBP . Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis . Also involved in glucose homeostasis in pancreatic islet (By similarity). May also act as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 . .

AccessionsENST00000306917.5
H3BT12
H3BTV3
ENST00000566008.1
Q9UK73
ENST00000566739.1