NLRP12 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NLRP12 at tissue level.

III. Associated gene sets

GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0032692Biological processnegative regulation of interleukin-1 production
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0009968Biological processnegative regulation of signal transduction
GO_0007165Biological processsignal transduction
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0045751Biological processnegative regulation of Toll signaling pathway
GO_0045345Biological processpositive regulation of MHC class I biosynthetic process
GO_0032661Biological processregulation of interleukin-18 production
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0036336Biological processdendritic cell migration
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0071345Biological processcellular response to cytokine stimulus
GO_0050728Biological processnegative regulation of inflammatory response
GO_0043281Biological processregulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0070371Biological processERK1 and ERK2 cascade
GO_0001818Biological processnegative regulation of cytokine production
GO_0006915Biological processapoptotic process
GO_0050729Biological processpositive regulation of inflammatory response
GO_0031953Biological processnegative regulation of protein autophosphorylation
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008656Molecular functioncysteine-type endopeptidase activator activity involved in apoptotic process
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNLRP12
Protein nameNLR family pyrin domain containing 12
NACHT, LRR and PYD domains-containing protein 12 (Monarch-1) (PYRIN-containing APAF1-like protein 7) (Regulated by nitric oxide)
SynonymsRNO
PYPAF7
NALP12
DescriptionFUNCTION: Plays an essential role as an potent mitigator of inflammation . Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways . Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway . In turn, promotes bacterial tolerance . Inhibits also the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation . Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity). .

AccessionsENST00000324134.11 [P59046-1]
ENST00000391773.7 [P59046-7]
P59046
ENST00000345770.9
A0A0C4DH17
ENST00000391772.1
A0A0C4DFY3
ENST00000391775.7 [P59046-6]