TIAL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0017145Biological processstem cell division
GO_2000648Biological processpositive regulation of stem cell proliferation
GO_0072089Biological processstem cell proliferation
GO_0035332Biological processpositive regulation of hippo signaling
GO_0007281Biological processgerm cell development
GO_0006915Biological processapoptotic process
GO_2000637Biological processpositive regulation of miRNA-mediated gene silencing
GO_0006952Biological processdefense response
GO_0044194Cellular componentcytolytic granule
GO_0005764Cellular componentlysosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0140517Molecular functionprotein-RNA adaptor activity
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0003723Molecular functionRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTIAL1
Protein nameTIA1 cytotoxic granule associated RNA binding protein like 1
T-cluster binding protein (TIA1 cytotoxic granule-associated RNA binding protein-like 1, isoform CRA_a)
TIAL1 protein
Nucleolysin TIAR (TIA-1-related protein)
SynonymshCG_40603
DescriptionFUNCTION: RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation . Shows a preference for uridine-rich RNAs . Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 . Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) . Possesses nucleolytic activity against cytotoxic lymphocyte target cells . May be involved in apoptosis . .

AccessionsE7ETJ9
A0A087WX93
Q01085
ENST00000369086.1
ENST00000436547.7 [Q01085-1]
O15187
ENST00000369093.6 [Q01085-2]
ENST00000497671.5
E7ETC0
Q49AS9
A6NKZ9
ENST00000412524.5
ENST00000479729.1