CIDEA report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CIDEA at tissue level.

III. Associated gene sets

GO_0010890Biological processpositive regulation of sequestering of triglyceride
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_1900118Biological processnegative regulation of execution phase of apoptosis
GO_0035634Biological processresponse to stilbenoid
GO_0120009Biological processintermembrane lipid transfer
GO_0070417Biological processcellular response to cold
GO_0160077Biological processlipid droplet fusion
GO_0042981Biological processregulation of apoptotic process
GO_0019915Biological processlipid storage
GO_0001818Biological processnegative regulation of cytokine production
GO_0050995Biological processnegative regulation of lipid catabolic process
GO_0006915Biological processapoptotic process
GO_0001659Biological processtemperature homeostasis
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0006629Biological processlipid metabolic process
GO_1902510Biological processregulation of apoptotic DNA fragmentation
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0005811Cellular componentlipid droplet
GO_0005739Cellular componentmitochondrion
GO_0005740Cellular componentmitochondrial envelope
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0120013Molecular functionlipid transfer activity
GO_0070300Molecular functionphosphatidic acid binding

IV. Literature review

[source]
Gene nameCIDEA
Protein nameCell death activator CIDE-A variant 2 (Cell death-inducing DFFA-like effector a)
Cell death inducing DFFA like effector a
Lipid transferase CIDEA (Cell death activator CIDE-A) (Cell death-inducing DFFA-like effector A)
Synonyms
DescriptionFUNCTION: Lipid transferase that promotes unilocular lipid droplet formation by mediating lipid droplet fusion . Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage . Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC (By similarity). May also act as a CEBPB coactivator in epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein (By similarity). By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). When overexpressed, induces apoptosis; the physiological significance of its role in apoptosis is unclear (By similarity). .

AccessionsO60543
ENST00000522713.5
E5RJ03
ENST00000320477.10
Q8N5P9