AHCYL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044070Biological processregulation of monoatomic anion transport
GO_0006611Biological processprotein export from nucleus
GO_0006730Biological processone-carbon metabolic process
GO_0033353Biological processS-adenosylmethionine cycle
GO_0032412Biological processregulation of monoatomic ion transmembrane transporter activity
GO_0042045Biological processepithelial fluid transport
GO_0010765Biological processpositive regulation of sodium ion transport
GO_0038166Biological processangiotensin-activated signaling pathway
GO_0006915Biological processapoptotic process
GO_0051592Biological processresponse to calcium ion
GO_0031440Biological processregulation of mRNA 3'-end processing
GO_1990456Biological processmitochondrion-endoplasmic reticulum membrane tethering
GO_0016324Cellular componentapical plasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070062Cellular componentextracellular exosome
GO_0044233Cellular componentmitochondria-associated endoplasmic reticulum membrane contact site
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042802Molecular functionidentical protein binding
GO_0003723Molecular functionRNA binding
GO_0030234Molecular functionenzyme regulator activity
GO_0005515Molecular functionprotein binding
GO_0004013Molecular functionadenosylhomocysteinase activity

IV. Literature review

[source]
Gene nameAHCYL1
Protein nameS-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2)
Adenosylhomocysteinase (EC 3.13.2.1)
AHCYL1 protein
PRO0233 (S-adenosylhomocysteine hydrolase-like 1, isoform CRA_a)
SynonymsDCAL
hCG_38162
XPVKONA
IRBIT
DescriptionFUNCTION: Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria . Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis . In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 . When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion . Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 . Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition . May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state . Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression . In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity). .

AccessionsO43865
ENST00000359172.3 [O43865-2]
ENST00000393614.8 [O43865-2]
Q9BTL0
Q2NKW8
A0A024R0A8
ENST00000369799.10 [O43865-1]
Q9UI76