Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 27 studies | 27% ± 12% | |
astrocyte | 19 studies | 56% ± 22% | |
pericyte | 18 studies | 22% ± 7% | |
endothelial cell | 15 studies | 30% ± 15% | |
smooth muscle cell | 15 studies | 26% ± 9% | |
ciliated cell | 12 studies | 36% ± 18% | |
epithelial cell | 10 studies | 37% ± 20% | |
adipocyte | 9 studies | 20% ± 4% | |
basal cell | 8 studies | 29% ± 10% | |
oligodendrocyte precursor cell | 8 studies | 30% ± 11% | |
type II pneumocyte | 7 studies | 25% ± 11% | |
GABAergic neuron | 7 studies | 35% ± 16% | |
kidney loop of Henle epithelial cell | 7 studies | 25% ± 7% | |
microglial cell | 7 studies | 22% ± 6% | |
connective tissue cell | 7 studies | 25% ± 13% | |
macrophage | 7 studies | 21% ± 5% | |
type I pneumocyte | 6 studies | 25% ± 5% | |
secretory cell | 6 studies | 24% ± 7% | |
glutamatergic neuron | 6 studies | 41% ± 24% | |
oligodendrocyte | 6 studies | 25% ± 8% | |
ionocyte | 4 studies | 27% ± 9% | |
classical monocyte | 4 studies | 27% ± 11% | |
conventional dendritic cell | 4 studies | 26% ± 13% | |
abnormal cell | 4 studies | 27% ± 13% | |
neuron | 4 studies | 30% ± 13% | |
retinal ganglion cell | 4 studies | 44% ± 24% | |
myofibroblast cell | 4 studies | 25% ± 4% | |
retinal cone cell | 4 studies | 44% ± 10% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 20% ± 5% | |
goblet cell | 4 studies | 24% ± 4% | |
type B pancreatic cell | 3 studies | 53% ± 27% | |
brush cell | 3 studies | 31% ± 7% | |
club cell | 3 studies | 36% ± 10% | |
retina horizontal cell | 3 studies | 23% ± 5% | |
retinal pigment epithelial cell | 3 studies | 36% ± 15% | |
retinal rod cell | 3 studies | 17% ± 1% | |
Mueller cell | 3 studies | 18% ± 2% | |
hepatocyte | 3 studies | 30% ± 15% | |
muscle cell | 3 studies | 30% ± 6% | |
dendritic cell | 3 studies | 31% ± 15% | |
pancreatic ductal cell | 3 studies | 52% ± 29% | |
ependymal cell | 3 studies | 36% ± 22% | |
enterocyte | 3 studies | 22% ± 4% | |
enteroendocrine cell | 3 studies | 32% ± 1% | |
endothelial cell of vascular tree | 3 studies | 23% ± 2% | |
transit amplifying cell | 3 studies | 30% ± 14% | |
granule cell | 3 studies | 19% ± 2% | |
interneuron | 3 studies | 39% ± 20% | |
erythroblast | 3 studies | 23% ± 2% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 15 studies | 28% ± 15% | |
eye | 7 studies | 24% ± 8% | |
lung | 7 studies | 25% ± 10% | |
intestine | 5 studies | 20% ± 5% | |
liver | 4 studies | 23% ± 5% | |
pancreas | 3 studies | 46% ± 27% | |
peripheral blood | 3 studies | 25% ± 6% | |
uterus | 3 studies | 33% ± 20% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 26822.00 | 2642 / 2642 | 100% | 490.77 | 705 / 705 |
intestine | 100% | 9691.79 | 966 / 966 | 100% | 86.79 | 527 / 527 |
ovary | 100% | 10337.02 | 180 / 180 | 100% | 117.10 | 430 / 430 |
stomach | 100% | 9193.39 | 359 / 359 | 100% | 90.55 | 286 / 286 |
esophagus | 100% | 9201.56 | 1443 / 1445 | 100% | 97.88 | 183 / 183 |
breast | 100% | 9403.58 | 459 / 459 | 100% | 150.16 | 1115 / 1118 |
thymus | 100% | 10734.45 | 653 / 653 | 100% | 137.33 | 603 / 605 |
uterus | 100% | 9186.49 | 170 / 170 | 100% | 90.54 | 457 / 459 |
lung | 99% | 8588.38 | 575 / 578 | 100% | 101.48 | 1155 / 1155 |
kidney | 100% | 11480.71 | 89 / 89 | 99% | 109.87 | 896 / 901 |
bladder | 100% | 9857.62 | 21 / 21 | 99% | 86.74 | 499 / 504 |
prostate | 100% | 7548.87 | 244 / 245 | 99% | 98.51 | 498 / 502 |
pancreas | 98% | 5521.34 | 321 / 328 | 99% | 96.02 | 177 / 178 |
skin | 100% | 8350.82 | 1805 / 1809 | 97% | 95.55 | 460 / 472 |
liver | 96% | 4259.16 | 218 / 226 | 97% | 63.06 | 392 / 406 |
adrenal gland | 100% | 11089.46 | 258 / 258 | 92% | 56.27 | 211 / 230 |
adipose | 100% | 10267.77 | 1204 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 10393.51 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 5405.24 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 80.78 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 36.40 | 1 / 1 |
blood vessel | 100% | 7837.16 | 1333 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 90% | 64.13 | 72 / 80 |
heart | 90% | 4292.20 | 773 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 46.63 | 26 / 29 |
peripheral blood | 60% | 3195.67 | 559 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0044070 | Biological process | regulation of monoatomic anion transport |
GO_0006611 | Biological process | protein export from nucleus |
GO_0006730 | Biological process | one-carbon metabolic process |
GO_0033353 | Biological process | S-adenosylmethionine cycle |
GO_0032412 | Biological process | regulation of monoatomic ion transmembrane transporter activity |
GO_0042045 | Biological process | epithelial fluid transport |
GO_0010765 | Biological process | positive regulation of sodium ion transport |
GO_0038166 | Biological process | angiotensin-activated signaling pathway |
GO_0006915 | Biological process | apoptotic process |
GO_0051592 | Biological process | response to calcium ion |
GO_0031440 | Biological process | regulation of mRNA 3'-end processing |
GO_1990456 | Biological process | mitochondrion-endoplasmic reticulum membrane tethering |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0044233 | Cellular component | mitochondria-associated endoplasmic reticulum membrane contact site |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0042802 | Molecular function | identical protein binding |
GO_0003723 | Molecular function | RNA binding |
GO_0030234 | Molecular function | enzyme regulator activity |
GO_0005515 | Molecular function | protein binding |
GO_0004013 | Molecular function | adenosylhomocysteinase activity |
Gene name | AHCYL1 |
Protein name | S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) Adenosylhomocysteinase (EC 3.13.2.1) AHCYL1 protein PRO0233 (S-adenosylhomocysteine hydrolase-like 1, isoform CRA_a) |
Synonyms | DCAL hCG_38162 XPVKONA IRBIT |
Description | FUNCTION: Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria . Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis . In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 . When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion . Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 . Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition . May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state . Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression . In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity). . |
Accessions | O43865 ENST00000359172.3 [O43865-2] ENST00000393614.8 [O43865-2] Q9BTL0 Q2NKW8 A0A024R0A8 ENST00000369799.10 [O43865-1] Q9UI76 |