CSNK2A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_1901524Biological processregulation of mitophagy
GO_0007283Biological processspermatogenesis
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006302Biological processdouble-strand break repair
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0097421Biological processliver regeneration
GO_2001234Biological processnegative regulation of apoptotic signaling pathway
GO_0006915Biological processapoptotic process
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0021987Biological processcerebral cortex development
GO_0016055Biological processWnt signaling pathway
GO_1905818Biological processregulation of chromosome separation
GO_0031519Cellular componentPcG protein complex
GO_0005956Cellular componentprotein kinase CK2 complex
GO_0001669Cellular componentacrosomal vesicle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCSNK2A2
Protein nameCasein kinase 2 alpha 2
Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1)
SynonymsCK2A2
DescriptionFUNCTION: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine . Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection . May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response . During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage . Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation . Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites . Can also negatively regulate apoptosis . Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 . Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 . Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV . Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB . Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function . Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 . Acts as an ectokinase that phosphorylates several extracellular proteins . During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV . .

AccessionsH3BSA1
ENST00000565188.2
P19784
H3BNI9
ENST00000262506.8
ENST00000567730.6